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Cyrax
(Hive Bee) 10-19-02 00:36 No 370041 |
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DPPF price? Organometalic reactions, do they suck? | Bookmark | |||||
Check out p 8 of: ../rhodium/pdf /nickel-on-cha There you can see the use of a compound called 1,1'-bis(diphenylphosphanyl)-ferrocene (DPPF) as a ligand in organometallic reactions. I was intrigued by this, so I fetched the article about the aromatic amination by heterogeneous Ni°/C catalysis. The authors states the following: "Given the importance of aryl amines in a variety of contexts (e.g. pharmaceuticals), a potentially scaleable heterogenous process which utilizes inexpensive chloride precursors and nickel rather than palladium may provide a welcomed complement to existing protocols." Yeah right, I guess nickel is a pretty damned sure cheaper than palladium. But what about the 1,1'-bis(diphenylphosphanyl)-ferrocene? Looking at the molecular structure, I don't think this can be a cheap compound. Can someone please look up how much this DPPF costs (say 5 grams)? The reaction requires this specific ligand, they tried it with others - but it didn't work ... |
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PrimoPyro (Hive Prodigy) 10-19-02 00:57 No 370050 |
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Hmm | Bookmark | |||||
Fluka lists 1,1'-bis(diphenylphosphino)ferrocene (is this the same as your compound?) for $26/1g or 145$/10g. Aldrich has it for $25/g or $139/10g PrimoPyro |
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Cyrax (Hive Bee) 10-19-02 01:19 No 370064 |
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Yes, it's the same compound. | Bookmark | |||||
Yes, it's the same compound. Whow, that's rather expensive. In an example they use 50.5 mg Ni/C and 10.7 mg DPPF for 104.2 mg 4-chlorobenzonitrile. So, when you want to do a 100 g reaction, it will cost like $140 ... taken into account the ligand alone. Furthermore, the reaction requires n-BuLi ==> strictly dry conditions and an argon atmosphere. I wouldn't want to use that reaction at an industrial scale ... Thanks for looking this up, PrimoPyro. |
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