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Dysprosium
(Stranger)
12-19-03 02:40
No 477723
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Dopamine or Tyramine Synthesis
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Sorry to be a bother, does anyone know a place to find either synth, ive looked and only have found biological routes. If purchase is feasible tell me and ill devote some more time into looking if synthesis is too dificult, hopefully this is within rules i dont need an exact source.
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<span title="The signature"><hr>"Its better to live one day as a lion than a houndred years as a lamb."</span>
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<font color="#FF0033">Rhodium</font><br>
<i>(<span title="The user's title at the time of posting">Chief Bee</span>)</i><br>
<span title="Posting date">12-19-03 03:02</span><br>
<span title="Link to this post by using the markup [477729]">No 477729</span><br>
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<b title="The subject of this post">Dopamine/Tyramine</b>
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They can be had by synthesizing 3,4-methylenedioxyphenethylamine or 4-methoxyphenethylamine and then dealkylate the aromatic substituents with refluxing with 48% HBr. <br><br>What is your intended use for the substances?
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<span title="The signature"><hr><sup>The Hive - Clandestine Chemists Without Borders</sup></span>
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Dysprosium<br>
<i>(<span title="The user's title at the time of posting">Stranger</span>)</i><br>
<span title="Posting date">12-19-03 03:24</span><br>
<span title="Link to this post by using the markup [477735]">No 477735</span><br>
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<b title="The subject of this post">Hmm thats sound like too much work for the...</b>
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Hmm thats sound like too much work for the simple purposes i have which is comparing the alkaloid contents of 2 san pedro, one being doped with dopamine preferibly, tyramine if nesesary. <br>I wanna start with one of those but could always use tyrosine which is more easily had but thats getting far up the mescaline cycle and risking not getting valid results at the time of extraction if most of the extraction is really unused tyrosine.
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<span title="The signature"><hr>"Its better to live one day as a lion than a houndred years as a lamb."</span>
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<font color="#FF0033">Rhodium</font><br>
<i>(<span title="The user's title at the time of posting">Chief Bee</span>)</i><br>
<span title="Posting date">12-19-03 03:59</span><br>
<span title="Link to this post by using the markup [477743]">No 477743</span><br>
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<b title="The subject of this post">another route</b>
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It would also be possible to decarboxylate Dopa or Tyrosine, for example by using any of these procedures: <br><br><span title="Jump to this post"><a href="../tryptamine/000416740.html#Post416740">Post 416740</a> <i>(Rhodium: "Novel amino acid decarboxylation via the nitrile", Tryptamine Chemistry)</i></span><br><span title="Jump to this post"><a href="../chemistrydiscourse/000285579.html#Post285716">Post 285716</a> <i>(foxy2: "Tyramine", Chemistry Discourse)</i></span>
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<span title="The signature"><hr><sup>The Hive - Clandestine Chemists Without Borders</sup></span>
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<font color="#ff0000">lugh</font><br>
<i>(<span title="The user's title at the time of posting">Moderator</span>)</i><br>
<span title="Posting date">12-19-03 04:15</span><br>
<span title="Link to this post by using the markup [477747]">No 477747</span><br>
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<b title="The subject of this post">Tyramine Preparations</b><br>
<i title="This post has been up-rated by the moderators">(Rated as: good read)</i>
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Here are some articles on tyramine synthesis<br><br>JACS 55, 2593, 3388 (1933):<br><br><a href="../picproxie_docs/000477723-buck.djvu" target="_blank" title="Download this file"><img src="../picproxie_imgs/djvu.gif"></a><br><br>Ber 64, 1510 (1931)<br><br><a href="../picproxie_docs/000477723-slotta.djvu" target="_blank" title="Download this file"><img src="../picproxie_imgs/djvu.gif"></a><br><br>Arch Pharm 270, 340 (1932)<br><br><a href="../picproxie_docs/000477723-kindler.djvu" target="_blank" title="Download this file"><img src="../picproxie_imgs/djvu.gif"></a><br><br><img src="../forum/images/icons_lightgrey/cool.gif" alt="cool" title="Cool" heigth="15" width="15">
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<span title="The signature"><hr>Chemistry is our Covalent Bond</span>
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methymouse<br>
<i>(<span title="The user's title at the time of posting">Stranger</span>)</i><br>
<span title="Posting date">01-09-04 13:59</span><br>
<span title="Link to this post by using the markup [481406]">No 481406</span><br>
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<b title="The subject of this post">Decarboxylation of tyrosine?</b>
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Both tyrosine and L-Dopa are fairly available. I know at least tyrosine can be purchased in a powder form for something like $10/oz. L-dopa can be extracted from some kind of plant which is also rather available. TFSE or Google should turn up the information. These could then be decarboxylated (to tyramine and dopamine resp.) by heating with a ketone catalyst in a high boiling point solvent. Look at student's spearmint catalyzed decarboxylation of tryptophan in turpentine on Rhodium's site. I expect that it should work similarly for phenylalanines like tyrosine. The only concern which comes to mind is that the hydroxyl group(s) might oxidize at those temperatures (at least on L-dopa this seems likely). I think that none of this is necessary, though, since tyrosine is part of the biosynthesis of mescaline, at least in peyote. See <a href="http://www.usm.maine.edu/~newton/Chy251_253/Lectures/AminesII/alkaloids.html" target="_blank" title="Jump to this external site">this site.</a> (http://www.usm.maine.edu/~newton/Chy251<wbr>_253/Lec<wbr>tures/Am<wbr>inesII/a<wbr>lkaloids<wbr>.html) <wbr> <br><br>Be sure to wait a long time before harvesting, since otherwise you'll get mainly whatever you injected into the cactus <img src="../forum/images/icons_lightgrey/tongue.gif" alt="tongue" title="Tongue" heigth="15" width="15">. Tyrosine has its purposes (for example, it seems to help with amphetamine hangovers), but certainly lacks the sparkle of mescaline <img src="../forum/images/icons_lightgrey/laugh.gif" alt="laugh" title="Laugh" heigth="15" width="15">
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<span title="The signature"><hr>I've got the kind of toys you've never seen<br>Manmade and a bit obscene</span>
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methymouse<br>
<i>(<span title="The user's title at the time of posting">Stranger</span>)</i><br>
<span title="Posting date">01-09-04 14:01</span><br>
<span title="Link to this post by using the markup [481407]">No 481407</span><br>
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<b title="The subject of this post">Oops</b>
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I missed Rhodium's post above. Sorry about any redundancy...
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<span title="The signature"><hr>I've got the kind of toys you've never seen<br>Manmade and a bit obscene</span>
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amine<br>
<i>(<span title="The user's title at the time of posting">Hive Bee</span>)</i><br>
<span title="Posting date">01-09-04 22:24</span><br>
<span title="Link to this post by using the markup [481465]">No 481465</span><br>
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<b title="The subject of this post">Dopamine via. Vanillin.</b>
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Edit: n/m there are easier methods posted above.<br><br>Dopamine is 3,4-dihydroxy-phenethylamine.<br><br>Why not demethylate the 3-methoxy group on vanillin via the pyridine.hcl/microwave method.<br>(<a href="../rhodium
/methylenation.html" target="_blank" title="Jump to this external site">../rhodium
/methyle<wbr>nation.h<wbr>tml</a>)<br><br>then condense via nitomethane<br>reduce via your favorite reducing agent.
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