malvaxman
(Newbee) 10-26-01 01:40 No 228818 |
Amination of L-PAC | Bookmark | ||||||
To methylaminate L-PAC to get ephedrine one must use reductive amination or some similar method. Converting L-PAC to 1-phenyl-1-hydroxy-propan-2-amine should be more easy, just: Ph-CH(OH)C(=O)CH3 + NH3 --> Ph-CH(OH)C(=NH)CH3 Ph-CH(OH)C(=NH)CH3 + H2O ---> Ph-CH(OH)CH(NH2)CH3 Could someone please tell me how the converting of keton to amine should be done technicaly. I have seen many papers on reduktive amination but no one yet on this reaction. Should the amonia be anydrous gas, or is possible with amonia(aq)? I know the yelds are low, about 30%, but by removing the product it should be possible to get more out of the reaction shouldn´t it? Is there any name of Ph-CH(OH)CH(NH2)CH3 (as Ph-CH(OH)C(NHCH3)CH3 is ephedrine)? I know this qustions are not very high-tech but I would be happy to get an answer. Thanx! |
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foxy2 (Distinctive Doe) 10-26-01 01:56 No 228822 |
Re: Amination of L-PAC | Bookmark | ||||||
Look at any synth of meth from P2P or any synth of MDMA/MDA from MDP2P. Adjust for the different molecular weight and procede from there. These are ALL OVER RHODIUMS site, and The HIVE. UTFSETM Do Your Part To Win The War |
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