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Giuseppi
04-08-02 20:47
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<i title="This post has been downrated by the moderators">(Rated as: crossposted)</i>
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pickler<br>
<span title="Posting date">04-08-02 21:09</span><br>
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wolfx<br>
<i>(<span title="The user's title at the time of posting">Hive Bee</span>)</i><br>
<span title="Posting date">04-08-02 21:11</span><br>
<span title="Link to this post by using the markup [294441]">No 294441</span><br>
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<b title="The subject of this post">A few mistakes</b>
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I don't have a solid organic chemistry background, but I think I see a few mistakes :<br><br>1) I think you should have used allylbenzene, and NOT benzaldehyde.<br><br>2) What you are calling a "REDUCTION" in fact is an oxidation, you convert the isosafrole ( or analogous molecule withouth the methylenedioxy ring ) to the ketone ( in your case P2P ). Easier to do a Wacker oxidation, though.<br>If you use the Wacker you won't need to isomerize the safrole ( or allylbenzene ).<br><br>3) The last step is amination plus reduction. If you follow the recipe it might work. I suggest you scale it down from TSII, I use 40 g ketone.<br><br>4) Don't give it a try if you are not really sure, study and post questions, otherwise, it is dangerous, also a waste of time and reagents. Other bees who know more chemistry might help you more than me.<br><br>5) The iodine etc. is the easy way, but reagents suspicious, difficult to get.<br>
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