alchemy_bee (Hive Bee)
04-25-02 07:46
No 301255
       Grignard side products  Bookmark   

After Hydrolysis of the grignard reagent eg with dilute HCl What are the side products? Im currious to understand what happends to the NMgCl complex.


Can a bee be visa vis its entity when half a bee philosophically must ipso facto half not be? 		 
 
 
 
    Rhodium
(Chief Bee)
04-25-02 10:26
No 301301
       Mechanism  Bookmark   

The =NMgCl complex reacts with HCl to give MgCl2 and the imine =NH, and the imine is then hydrolyzed by H2O/HCl to give the ketone =O and NH4Cl. 		 
 
 
 
    alchemy_bee
(Hive Bee)
04-25-02 17:23
No 301411
       grignard reactions  Bookmark   

Whow thats great Rhodium, its easy to see how water is detramental to NaBH3 reductions of P2Ps.

Can you explain the attraction/reaction of the nitrogen in the methyl cyanide to the grignard set (MgCl)?


To any bees interested in grignard reactions http://www.chem.ucalgary.ca/courses/351/Carey/Ch14/ch14-3-1.html is a good read.




Can a bee be visa vis its entity when half a bee philosophically must ipso facto half not be? 		 
 
 
 
    Rhodium
(Chief Bee)
04-26-02 04:12
No 301603
       RMgX + RCN  Bookmark   

One of the resonance forms of a nitrile is R-C+=N- and the grignard reagent is equivalent to a R- anion, therefore it adds to the nitrile carbon.