(Hive Bee)
06-25-03 12:19
No 442506
(Rated as: good read)
Some Recent Applications of
-Amino Nitrile ChemistyChem. Soc. Rev., 29 (5), 359-373 (2000) (http://www.rsc.org/CFmuscat/intermediat
DOI:10.1039/a908290e
Abstract
Bifunctional
-amino nitriles are not only versatile intermediates in organic synthesis but also exhibit a valuable dual reactivity, which has been utilized in a broad range of synthetic applications. This review highlights recent developments in the chemistry of -amino nitriles, including asymmetric synthesis of -amino acids via Strecker reactions using chiral auxiliaries and catalysts, -amino nitriles as masked iminium ion equivalents in cationic reactions and the synthesis of natural products and heterocycles, and -metallation to provide nucleophilic acyl anion equivalents and applications to asymmetric Umpolung reactions.
We're all in this world together,
http://www.chiapaslink.ukgateway.net/
(Chief Bee)
06-25-03 17:08
No 442551
Were you thinking of any specific applications of this substance class, or did you just want to share the free review?
(Hive Bee)
06-25-03 19:16
No 442579
In the (Scheme 26 )Summary of reactions of lithiated a-amino nitriles.
Notice that the production of P2P ketone and diketones in the reaction with lithiated amino nitriles, that cought my eye and could be exploited say using a cheap OTC Phenylalanine amino acid.......java
We're all in this world together,
http://www.chiapaslink.ukgateway.net/