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Fatass
(Newbee) 08-09-03 14:14 No 452659 |
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Homomyristicylamine; a worthy target? | Bookmark | |||||
While just browsing the net, I came across this link from Lycaeum: http://leda.lycaeum.org/?ID=16291 It is a collection of three papers by Shulgin on the topic of Mescaline. One paragraph caught my attention: A fourth compound is homomyristicylamine (lophophine, 9) which also has never been observed in the peyote plant, but which presents an obvious theoretical potential as a biosynthetic precursor of the tetrahydroisoquinoline alkaloids such as lophophorine and anhalonine. This compound is active in man at dosage levels of 150 to 200 mg, about twice the potency of mescaline (18). The quali- tative description of its action is quite similar to that of mescaline, in that there is a peaceful elevation of mood, the generation of an euphoric state, and the enhancement of visual perception especially in the color sense. There are dis- similarities, particularly in that there is little if any nausea and there is no visual distortion. These latter differences disappear at dosages of 300 mg and there is the generation of eyes-closed imagery similar to that observed with mescaline.[i] The compound is basically 3,4-methylenedioxy-5-methoxyphenthylamin Of course, the precursor, 3,4-methylenedixoy-5-methoxybenzaldehyde So all in all, anyone have any experience with this compound? Is the whole day a waste if you are wasted the whole day? |
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yellium (I'm Yust a Typo) 08-09-03 14:32 No 452661 |
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YM pikhal #95? | Bookmark | |||||
YM pikhal #95? |
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Aurelius (Active Asperger Archivist) 08-10-03 15:29 No 452832 |
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3,4-MD-structures | Bookmark | |||||
Are all watched. Especially since it's a benzaldehyde. I wouldn't count on easily obtaining the stuff w/o owning/working for a legit lab. Act quickly or not at all. |
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Vitus_Verdegast (Hive Bee) 08-10-03 17:38 No 452851 |
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5-OH-vanillin | Bookmark | |||||
Maybe you should try methylenation of 5-hydroxyvanillin ? ../rhodium /mmda.me A Dream Within A Dream (http://www.poedecoder.com/Qrisse/works/ |
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hypo (Hive Addict) 08-11-03 00:50 No 452934 |
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or oxidation of myristicin, | Bookmark | |||||
which would be my first try. |
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GC_MS (Hive Addict) 08-11-03 03:00 No 452949 |
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myristicinaldehyde (Rated as: good read) |
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or oxidation of myristicin, which would be my first try. [...] The third route, that which starts with myristicin, appeared to be the only practical synthesis of the title compound. Base-catalyzed isomerization to isomyristicin places the double bond in a position appropriate to an aldehydic end product. KMnO4 has been employed in a number of procedures to provide the final aldehyde, but there is concurrent formation of the corresponding benzoic acid. Hydrogen peroxide with a vanadium catalyst precludes acid formation but still provides only modest yields. It has only been through ozonolysis that sizable quantities of 4 have been prepared but here minor variations in the reaction conditions seriously affect the yields realized. [...] Myristicinaldehyde An intimate mixture of 50 g 2 (1-(3-methoxy-4,5-methylenedioxyphenyl)- Complete integrity of the ether orientation was established by the reconversion of 4 (myristicinaldehyde) to 2 with nitroethane as has been described for the trimethoxy counterpart. [...] note: 2 was prepared from isomyristicin using tetranitromethane. reference: A Shulgin. Can J Chem 46 (1968) 75 Dirty old man |
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cattleprodder (Hive Bee) 08-11-03 17:54 No 453045 |
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lophophine | Bookmark | |||||
myristicin (KMnO4 under the right conditions) --> vicinal diol (HIO4) --> NaBH3CN + ammonium acetate --> lophophine These reaction specifics still need looking up, however. |
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