java
(Hive Bee)
11-23-03 19:13
No 472765
      Solvent -Free Accelerated Organic Synthesis..
(Rated as: good read)
    

Solvent -Free  Accelerated Organic Syntheses using Microwaves

Pure Appl.Chem. vol.73, No.1,pp.193-198 (2001)

http://www.iupac.org/publications/pac/2001/pdf/7301x0193.pdf

Abstract.A solvent-free approach for organic synthesis is described which involves microwave (MW) exposure of neat reactants (undiluted) either in the presence of a catalyst or catalyzed by the surfaces of inexpensive and recyclable mineral supports such as alumina, silica, clay, or "doped" surfaces, namely, Fe(NO3)3-clay (clayfen), Cu(NO3)2-clay (claycop), NH2OH-clay, PhI(OAc)2-alumina, NaIO4-silica, MnO2-silica, and NaBH4-clay. A variety of deprotection, condensation, cyclization, oxidation, and reduction reactions are presented including the efficient one-pot assembly of heterocyclic molecules from in situ generated intermediates such as enamines and a-tosyloxyketones. The application of this solvent-free MW approach to multicomponent reactions is highlighted that can be adapted for high-speed parallel synthesis of the library of dihydropyrimidine-2(1H)-ones and imidazo [1,2-a]annulated pyridines, pyrazines, and pyrimidines.

We're  all in this world together,
http://www.aztlan.net