kjb1891
(Stranger) 05-28-04 10:57 No 510074 |
Unheard of amphetamine | |||||||
Hey bees. Does anyone know if this old post has any validity or any new info about it? alpha-Fluoroamphetamine? Post 293679 (R57: "alpha-Fluoroamphetamine?", Chemistry Discourse) Posted by R57 I know I'm not the first to talk about alpha-Fluoroamphetamine (Rhodium, post 259909) but this looks quite simple: 1. Reduce phenylalanine (in anhydrous ether) to phenylalaninol using Lithium Aluminum Hydride. 2.Fluorinate phenylalaninol with diethyl ammonium sulfur trifluoride (DAST) to give alpha-Fluoroamphetamine. Two questions though: (forgive my ignorance) a)With DAST being trifluoride, does this mean it will give up 3 moles of fluoride ions for 1 mol DAST (it's very expensive so this is quite important) i.e. will 1 mol DAST fluorinate 3 moles phenylalaninol? b)Would recrystallisation/purification be necesasary between the first and second step, or could the DAST be added straight to the reaction mixture? I assume this will give the free base, so I can make the salt quite simply. Any info will bee very much appreciated! |
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