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Knoevenagel
(Stranger) 04-04-02 02:56 No 292084 |
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N-formylation of primary amine | Bookmark | |||||
Hi On basis of your knowledge how would you perform an N-formylation of amphetamine in the best possible way? / Knoevenagel |
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Rhodium (Chief Bee) 04-04-02 08:15 No 292193 |
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N-formylation | Bookmark | |||||
Reflux it with formic acid in toluene with a dean-stark water trap or reflux with ethyl formate. |
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Knoevenagel (Stranger) 04-04-02 19:56 No 292390 |
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MDA v. amph | Bookmark | |||||
Hi Rhodium I´ve seen the post on amph -> meth on the Rhodium page(Ref: Phikal) page but this is for MDA. Does MDA have the same the reactivity towards formylation with HCOOH as the amph. Do you think the methylenedioxy-group interferes in some way with regards yields/reactivity? /Knoevenagel |
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Rhodium (Chief Bee) 04-05-02 00:18 No 292497 |
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mda/amph | Bookmark | |||||
No, amphetamine should react exactly like MDA in this case. |
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Knoevenagel (Stranger) 04-06-02 03:22 No 293065 |
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formyl chloride? | Bookmark | |||||
RHODIUM! Why formic acid, why not formyl chloride?. Any problems with this reactant as far as you concern? Shouldn´t this decrease reaction time, increase yield etc? / Knoevenagel |
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terbium (Old P2P Cook) 04-06-02 04:33 No 293084 |
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Formyl chloride. | Bookmark | |||||
Perhaps because formyl chloride can be a bit difficult to acquire. I doubt that it can be purchased, it isn't stable enough. One would have to try to make it as needed. |
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