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Cyrax (Hive Bee) 10-09-02 03:58 No 366431 |
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Diampromide (Rated as: excellent) |
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Diampromide was develloped at the American Cyanamid Company, by some chemists who modified the methadone molecule a bit. Preliminary clinical results indicate that the potency of diampromide lies between that of meperidine and morphine. Synthesis: A benzene solution of N-methylphenethylamine(1) and 2-bromopropionanilide(2) was heated under reflux to give 2-(N-methylphenethylamino)-propionanilid Precursors: (1) J. Chem. Soc. (1910) p 2253 (2) Ber. (1892) vol 25 p 2919 Ref.: JACS (1959) vol 81 p 1518 - 1519 A comparison between diampromide, 2,3-seco-fentanyl and fentanyl can be found at: http://www.ch.ic.ac.uk/ectoc/echet98/pub Diampromide seems to be 167 times less potent than fentanyl. Hence, I estimate that the dose would be 4 - 8 mg. |
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Bwiti (PVC-Analog Taste-Tester) 10-09-02 04:18 No 366435 |
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Sweet! I wonder if Na-borohydride/nickel boride ... | Bookmark | |||||
Sweet! I wonder if Na-borohydride/nickel boride could replace the LAH? If diampromide is more euphoric and less sedating than prodine or analogs, then it would be worth making. Peace! ![]() Love my country, fear my government. |
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Cyrax (Hive Bee) 10-09-02 10:26 No 366541 |
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refs. (Rated as: excellent) |
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I don't know if the P-2 catalyst (normally used to reduce alkenes) can be used to reduce amides ... But I have refs. for coreactants that can be used with NaBH4 to reduce amides: * Tetrahedron Lett. (1969) p 4555 * Tetrahedron Lett. (1976) p 219 * J.Org. Chem. (1977) vol 42 p 2082 * J.Org. Chem. (1981) vol 46 p 2579 * Synthesis (1987) p 1128 * Chem. Lett. (1990) p 251 Mabey Ni2B is one of them. I know it will work with BF3 or Me3SiCl as a coreagent. BF3 + NaBH4 will in situ generate borane (cfr. J. Org. Chem. (1973) vol 38 p 912). And trichlorosilane even reduces amides without NaBH4. Ref.: Chem. Lett. (1972) p 989. What looks promessing, is that all kinds amides can be reduced with Na in 1-propanol. However, the article is somewhat difficult to obtain: Chem. Ind. (London) (1990) p 547. Bwiti, I would say: up to the library ![]() |
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