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silenziox
(Stranger) 10-26-03 18:00 No 466868 |
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Sonochemistry, reductions | ||||||
Here are couple of excellent publications of sonication links: 1. Petrier C.; Suslick, K. S. "Ultrasound-Enhanced Reactivity Of Calcium In The Reduction Of Aromatic Hydrocarbons" Ultrasonics Sonochemistry 2000, 7, 53-61. (http://www.scs.uiuc.edu/suslick/pdf/uss 2. - Suslick, K. S.; Casadonte, D. J. "Heterogeneous Sonocatalysis with Nickel Powder" J. Am. Chem. Soc. 1987, 109, 3459-3461. (http://www.scs.uiuc.edu/suslick/pdf/jac "However, when using Nickel powder as catalyst, no reduction of ketones or aldehydes was observed". "Compared to Raney Ni, however, our activated Ni-powder is more selective (C-O double bonds are untouched). Reaction runs at 273K with 1atm H2. Octane was used as solvent. Interesting indeed. It should work with nitrostyrenes then, which makes this shit cheap as hell ![]() ... My dream: -Nitroalkene with ultrasound (../rhodium /nitros modified to produce DL-threo-substituted-nitroalkenes for optical resolution (../rhodium /norpse - Collecting the nitromethane/nitroethane and nitroalkene using rotovap, recrystallation of the nitroalkene - reduction of the nitroalkene with either: 1. calcium as sonocatalyst, 2. Ni-powder as sonocatalyst, 3. Pd/C as sonocatalyst (much less Pd/C to use?) - resolving the reduced nitroalkene into optically pure isomers - converting the inactive isomer into active one by oxidation and re-amination etc. - other workup as the favoured compound requires ![]() Yields should be quite appealing ![]() Better overdose than lowerdose |
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