![]() |
![]() |
|||||||
roddyjojo
(Stranger) 11-30-03 09:50 No 473856 |
![]() |
Hydrocodone | ||||||
../rhodium /dihydro Regarding the text available at the posted link, and the codeine -> dihydrocodeinone (hydrocodone) by rearrangement, can Nickel (Nickel metal or Nickel on Aluminum) be used in place of Pd/Pt in this reaction? I've read somewhere that it can but at some sacrifice to yields, however cannot recall the source. Also if a powdered mixture of Nickel and Copper and roughly evening amounts was used, how would the presence of the Copper affect the reaction? Thanks |
||||||||
![]() |
![]() |
|||||||
![]() |
![]() |
|||||||
bouncer (Stranger) 12-12-03 02:37 No 476268 |
![]() |
Has anyone done such synth: codeine ->... | ||||||
Has anyone done such synth: codeine -> dihydrocodeinone (hydrocodone) ? It seems as it would be very mg efficient (less hydrocodone is needed than codeine to achieve euphoria) |
||||||||
![]() |
![]() |
|||||||
![]() |
![]() |
|||||||
algebra (Hive Bee) 12-12-03 05:01 No 476299 |
![]() |
No - do more reading... | ||||||
No - do more reading... LoneR says that Pd in dry toluene (rather than acidic aqueous solution) yeilds 30% (see alt.d.c). note even rapoport was apparently unable to replicate this hydrogenation/dehydrogenation to obtain the hydrogenated ketone with any kind of yield. |
||||||||
![]() |
![]() |
|||||||