SilverSurfer (Hive Bee)
12-05-03 09:32
No 474839
      reduction of isonicotinic acid     

Reffering to demerol synth
[url=../rhodium /pethidine.html]

Why isnt the reduction of the isonicotinicacid step one,
instead reducing it before methylating

Is there recently a more practically way of reducing it?

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    Rhodium
(Chief Bee)
12-05-03 13:24
No 474871
      why     

N-Alkyl-pyridinium salts are more easily reduced than the plain pyridines.