03-07-04 20:08
No 493691
So, SWIM has questions about doing bromination of 2,5-dimethoxy-PEA HCl into 2CB HBr. All you have to do is bring a solution of 2CH and GAA to a good stir. Then, add a solution of elemental bromine and GAA. Once it forms a brown crystaline mass and returned to room temps it can be cleaned up with acetic acid and ethyl acetate to give fairly good 2CB HBr. Is there anything else to it?
(Hive Bee)
03-07-04 20:18
No 493694
click on the PIHKAL link on the bottom of the page, then click on 2C-B.
(Hive Bee)
03-08-04 08:54
No 493766
Just in case, you will need a fume hood or something like that, because of the very iritating and toxic bromine fumes.
Also, transfering the bromine with a pipette is difficult because it vaporizes and falls from the pippete.
There are alternative bromination procedures whithout using bromine. I have never tried any nor the bromine either, though. There is also a lot of posts, use TFSE.
(Chief Bee)
03-08-04 10:59
No 493783
../rhodium /2cb.bro
The Hive - Clandestine Chemists Without Borders
(Stranger)
03-08-04 11:26
No 493788
Chilling the bromine would help reduce the evaporation wouldn't it?
(Chief Bee)
03-08-04 11:32
No 493789
Yes, that is also covered in the document I linked.
The Hive - Clandestine Chemists Without Borders
(Stranger)
03-08-04 13:40
No 493804
Would the acetic acid and ethyl acetate be sufficient enough for getting rid of impurities? Thanks for all the info
(Hive Bee)
03-09-04 06:09
No 493946
No this will not get rid of all the impurities, washing the compound afterwards with cold dry ether followed by a recrystallisation will remove most impurities.
Hippler
(Stranger)
03-10-04 11:54
No 494245
I meant to say washing with the acetic acid, but doing a recrystallization with the ethyl acetate as the solvent. Or is there a better solvent to use?
(Hive Bee)
03-11-04 02:44
No 494362
A suggestion might bee washing with ethyl acetate followed by cold dry ether and for the recrystalisation either ether/methanol or ether/ipa.
Hippler