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periannath
(Stranger) 03-15-03 20:48 No 417492 |
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Alkylation of amines | Bookmark | |||||
(I was going to post this to the tryptamine forum but since this could be applicable to any amine I decided to post here.) Say I had just reduced melatonin to 5-MeO-NET with LiAlH4 or whatever and reacted it with an excess of methyl iodide to form the quaternary ammonium salt 5-Methoxy dimethylethyltrypammonium iodide. I would get a mixture of 5-MeO-DMT and 5-MeO-MET when I dequat. Correct? ![]() Wherever you go, there you are. -Buckaroo Banzai |
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periannath (Stranger) 03-16-03 17:53 No 417812 |
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Is there anybody out there. | Bookmark | |||||
All I need is a simple yes or no. If no I would appreciate a reason. Wherever you go, there you are. -Buckaroo Banzai |
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Rhodium (Chief Bee) 03-17-03 16:02 No 418202 |
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You will likely get almost exclusively ... | Bookmark | |||||
You will likely get almost exclusively 5-MeO-MET, as methyl groups are removed preferentially in most dequaternization reactions. |
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periannath (Stranger) 03-17-03 16:35 No 418220 |
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Thanks | Bookmark | |||||
Thanks! That was the answer I was hoping for. However I now realize It might be easier methylated with formaldehyde. ![]() Wherever you go, there you are. -Buckaroo Banzai |
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Rhodium (Chief Bee) 03-18-03 15:33 No 418809 |
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Tryptamine methylation | Bookmark | |||||
If you UTFSE you will see that not many formaldehyde methylations are tryptamine-friendly (NaBH3CN being an exception). |
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