09-12-03 11:23
No 458597
where does the Na bind to form the salt? On the NH2 or the SO2NH2?
-jsx
(Chief Bee)
09-12-03 19:16
No 458687
Sulfanilamide is most easily deprotonated on the sulfonamide nitrogen: http://acpcommunity.acp.edu/Facultystaff
(Hive Bee)
09-13-03 17:10
No 458868
Why is this?
Secondly, would it be correct to assume that the Sulfur containing substitute has something to do with the toxicity?
-jsx
(Chief Bee)
09-13-03 17:18
No 458869
1) The reason why is explained in the PDF - it has to do with certain resonance structures.
2) I don't understand the question.
(Hive Bee)
09-13-03 17:22
No 458870
OK, thanks I'm reading the pdf right now.
About the second question. Why is this substance toxic? I read somewhere (don't have refrence) that 100 people died in the 30's in the states cause of this drug..
-jsx
(Hive Bee)
09-13-03 17:25
No 458871
Ok apparently the poor water solubility is the reason of the nephrotoxicity. And thus droping the pKa will lesson the toxicity. Substituting the sulfoamide nitrogen atom.
-jsx
(Chief Bee)
09-13-03 17:52
No 458875
OK, thanks I'm reading the pdf right now.
Huh? Didn't you even bother to read the reference I retrieved for you before asking more questions? Is there a limit to laziness?
(Hive Bee)
09-15-03 13:37
No 459181
Huh? Didn't you even bother to read the reference I retrieved for you before asking more questions? Is there a limit to laziness?
Uh, in my case, no. Sorry, actually there's no point in asking anything, for all the answers one could find in either books, TFSE, via google etc.
-jsx