aleph (Stranger)
10-28-03 00:27
No 467124
       Sodium Borohydride vs Sodium Cyanoborohydride     

Anyone have a clue whether sodium borohydride rather than sodium cyanoborohydride will work in Strike's (Total Synthesis II) method #1 (page 98)?

A post I have seen indicates it may be a possibility, but indicates the use of methylamine gas.  I was hoping for the easy reaction in Strike's book without cyanoborohydride.
Braille lips for blind bees? 		 
 
 
 
    cublium
(Newbee)
10-28-03 06:50
No 467211
       Borohydride will work with methylamine just...     

Borohydride will work with methylamine just fine althought cyanoborohydride will give slightly higher yields(it doesn't reduce ketone to alcohol,which borohydride does,but only imine to amine). 		 
 
 
 
    aleph
(Stranger)
10-29-03 23:32
No 467661
       Thanks     

Thanks for the info.
Tolerance is a sign of maturity.