03-11-04 15:34
No 494400
When you run the leuckart with dimethylformamide you will get the desired amine directly after the reaction with no formyl intermediate. But i'm a bit concerned about the workup. In one example in ../rhodium/pdf /leuckart.pdf they basify with NaOH and then steamdistill. That will ofcourse release much dimethylamine into the air as the DMF is hydrolised, which isn't so nice.
Could you possibly after the reaction extract with DCM (as the amine should be in formate salt) and then basify and extract the amine as usual in an A/B? Is DMF soluable in DCM?
(Chief Bee)
03-11-04 19:42
No 494434
Is DMF soluable in DCM?
Yes, it's miscible with both water and DCM.
The Hive - Clandestine Chemists Without Borders
(Old P2P Cook)
03-12-04 05:15
No 494554
When you run the leuckart with dimethylformamide you will get the desired amine directly
Why do you desire a dimethylamphetamine?
All those moments will be lost in time, like tears in rain.
(Hive Bee)
03-12-04 14:14
No 494619
No, I was going to run it on deoxybenzoin to get lefetamine.
(Chief Bee)
03-12-04 17:17
No 494652
While lefetamine undoubtedly is a psychoactive compound, it is very weak and has little recreational potential. Consider reductive amination of desoxybenzoin with N-cyclohexylpiperazine instead. The resulting compound is much stronger, see Post 281338 (Rhodium: "Lephetamine/Lefetamine", General Discourse)
The Hive - Clandestine Chemists Without Borders
(Hive Bee)
03-12-04 17:48
No 494654
Yes, i have read that info. However, I want to first make lefetamine for the ease of the reaction, and then perhaps consider making the more potent analogue. And also, I want to get a dean stark trap before trying out the synth of that, as I would probably do it by reductivly aminating with diethanolamine, chlorinating and then reacting with cyclohexylamine (N-cyclohexylpiperazine is pretty expensive).