xxxxx (Stranger)
04-27-04 12:51
No 503363
       vitamin b1 to sedative?     

i read someplace that sodium bisulfite is supposed to break vitamin b1 into two parts, one of which is a controlled substance (sedative). this is all i have. i don't even remember the name of the sedative, although i think the dose was 100mg. this was mentioned in pills a go-go (book) which names sedative compound and dose but chemical literature stated cleaving compound as sodium bisulfite, not compound stated in pills a go-go. can anyone confirm or deny foregoing? 		 
 
 
 
    Rhodium
(Chief Bee)
04-27-04 18:28
No 503399
       Thiamin (Vitamin B1) Cleavage w/ sulfite     

Yes, Vitamin B-1 can be cleaved with bisulfite:



However, the alcohol formed - 2-(hydroxyethyl)-4-methyl-thiazole - needs to have its OH group substituted with a chlorine atom before the result becomes the anxiolytic/hypnotic Clomethiazole.
The Hive - Clandestine Chemists Without Borders 		 
 
 
 
    Lestat
(Hive Bee)
06-24-04 21:11
No 515281
       Rhodium, would gassing with Cl2 be sufficient...     

Rhodium, would gassing with Cl2 be sufficient for the chlorination? or must some other method bee used? this sounds like an interesting synthesis.
A politician is like a baby's nappy, it should be changed often and for the same reason. 		 
 
 
 
    Nicodem
(Hive Bee)
06-24-04 23:15
No 515295
       Thionylchloride     

Lestat: This is a nucleopylic substitution of the alcohol to the chlorine group - not the usual chloriantion with Cl2. You need reagents like SOCl2 or PCl3. Some alcohols can bee also substituted with conc. HCl but not the primary ones like this one.
“The real drug-problem is that we need more and better drugs.” – J. Ott 		 
 
 
 
    Lestat
(Hive Bee)
06-24-04 23:30
No 515299
       Hmmmm...I have to try this one, has me ...     

Hmmmm...I have to try this one, has me intrigued.
I would be quite interested in trying a nanoscale of this just to see what this stuff is likesmile
A politician is like a baby's nappy, it should be changed often and for the same reason. 		 
 
 
 
    PolytheneSam
(Faux News)
06-26-04 12:03
No 515575
       How about ZnCl2/HCl?     

How about ZnCl2/HCl?
http://www.geocities.com/dritte123/PSPF.html
 		 
 
 
 
    Lestat
(Hive Bee)
06-26-04 13:02
No 515594
       Might work, I'm not too experienced, so i'm...     

Might work, I'm not too experienced, so i'm just  gonna have wing it and hope for the bestsmile
A politician is like a baby's nappy, it should be changed often and for the same reason. 		 
 
 
 
    dr_moeselmann
06-29-04 14:08
       tertiary alcs?
(Rated as: UTFSE!)