07-25-04 09:18
No 521499
SWIM has read various articles on the topic of mostly codeine->oxycodone, but SWIM's final goal is not OXY, but rather hydrocodone (aka vicodin, norco). Dope_amine has written the fairly easy to understand workup of codeine->oxycodone, and arrives there with a middle step that produces "14-Hydroxycodeinone". Now is this Hydroxycodeineone what I am after? or is it another substance?
Thanks in advance
(Hive Bee)
07-25-04 18:43
No 521565
14-Hydroxycodeinone
is definitly not Hydrocodone (3-Methoxy-7,8 dihydromorphinon- 6)
The pos. 14 in codeine/morphine molecule with an Hydrogen on it is oxidated to give a Hydroxy there.
Hydrocodone has only an H there.
So you need to make Dihydrocodeine(3-Methoxy-7,8 dihydromorphine) from Codeine (3-Mehoxy- Morphine)
via hydrogenation.
Then oxidate this substance to have an double bonded
oxygen at pos. 6
If you would hydrogenate 14-Hydroxycodeinone you had
Oxycodone (3-Methoxy-14-Hydroxy-7,8 dihydromorphinon-6)
(Chief Bee)
07-28-04 16:26
No 522247
(Rated as: excellent)
A Rapid, Nearly Quantitative Conversion of Codeine to Hydrocodone
Black, T. H.; Forsee, J. C.; Probst, D. A.
Synth. Commun. 30(17), 3195-3201 (2000) (../rhodium /hydroc
Besides that recent article, there is also a series of infamous german patents from 1936 detailing a one-pot isomerization of Codeine to Hydrocodone using either palladium or platinum, available at ../rhodium /dihydro
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