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Alphabeta121
(Hive Bee) 08-02-00 02:27 No 35584 |
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Flouro Compounds | Bookmark | |||||
This isn't really kitchen chem compatable, but I'm wondering about flourination of desirable compounds, yeilding things like DO(triflouromethyl), 2C-(triflouromethyl), and 3,5 dimethoxy 4- triflouromethyl phenethylamine and phenisopropyl amine. for 2C-TF would one could a vilsmeyer rxn be performed on 2,5 dimethoxy 1 TFM benzene? Or would the TFM group be too electron withdrawing. Or perhaps start with 2 TFM hydroquinone in a basic solution, and do an ortho formylation, then methylate. I've only seen two halogenation reactions, replacement of halogen by KF/ 18- Crown-6 ether, and replacement of a diazonium salt by flouboric acid. Neither of those seem very applicable. Any help or even interest in this topic? try www.flourosolutions.com and ask the from a business account. alphabeta121 |
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Alphabeta121 (Hive Bee) 08-03-00 06:59 No 36066 |
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Re: Flouro Compounds | Bookmark | |||||
have the hive's world famous geniuses all died? |
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Rhodium (Chief Bee) 08-03-00 22:38 No 36296 |
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Re: Flouro Compounds | Bookmark | |||||
I have tried a knoevenagel reaction with trifluoromethylbenzaldehyde. The yield was dismal in several attempts, and the starting aldehyde very expensive. http://rhodium.lycaeum.org |
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Alphabeta121 (Hive Bee) 08-04-00 05:46 No 36409 |
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Re: Flouro Compounds | Bookmark | |||||
boner, so I guess that leaves a substituted acetonitrile reduction ala G_Pig? Sounds alright to me, but its the synthesis of the aldehyde that I'm interested in. |
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