dormouse
(Member) 04-25-00 00:04 No 108815 |
Synthesis of Toluene-hydroquinone? -psychokitty | Bookmark | ||||||
the Hive BB Novel Discourse Synthesis of Toluene-hydroquinone? profile | register | preferences | faq | search next newest topic | next oldest topic Author Topic: Synthesis of Toluene-hydroquinone? Synthesis of Toluene-hydroquinone? psychokitty Member posted 11-04-1999 06:42 PM ---------------------------------------- This question is primarily aimed at Rhodium. Just wondering if the proceedure detailed in an article I found published in JACS vol. 65, 1943, pp.1431-1432 titled "Some Derivatives of Creosol" has any application in the synthesis of 4-methyl-2,5-(dimethoxy) allylbenzene, a potential precursor to DOM. Basic outlined scheme is as follows: 1. Formation of the benzaldehyde from the methoxy-hydroxy benzene. 2. Conversion of aldehyde via the Clemmensen reduction into the hydroxy-methoxy-toluene. 3. Formation of the methoxy-methyl allyl-phenol ether from the hydroxy-methoxy-toluene and allylbromide. 4. Claisen rearrangement of the methoxy-methyl allyl-phenol ether into the allyl-hyroxy-methoxy-methyl-benzene. 5. Methylation of the phenolic group to form the desired allyl-dimethoxy-methyl-benzene. Don't know if I generallized the shit out of my intermediates to where no one can imagine what they look like, but I did my best. Rhodium, would this work? --PK --PK Contact Us | the Hive Powered by: Ultimate Bulletin Board, Version 5.39a |
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