Chemical_brain (Stranger)
04-17-01 07:17
No 184624
       Help to make 1,5-dibromopentane (Method). for PCP  Bookmark   

magnesium organometallicderivative of 1,5-dibromopentane
gives PCP. The only difficulty in this route is the preparation of
the dibromopentane Grignard reagent,
Reaction of N-benzoylpiperidine with the lithium or magnesium
organometallic derivative of 1,5-dibromopentane gives PCP. The only difficulty in this route
is the preparation of the dibromopentane Grignard reagent, with its strict requirement for
anhydrous conditions (Method ????).
  
 
 
 
    Rhodium
(Chief Bee)
04-17-01 14:35
No 184706
       Re: Help to make 1,5-dibromopentane (Method). for PCP  Bookmark   

Ring opening of tetrahydropyran with HBr, or bromination of 1,5-pentanediol with HBr (or red P + Br2).

http://rhodium.lycaeum.org 		 
 
 
 
    Chemical_brain
(Stranger)
04-21-01 08:01
No 185646
       Re: Help to make 1,5-dibromopentane (Method). for PCP  Bookmark   

It is possible something more About red P+Br2  and TGF+HBr
the description of process.
  
 
 
 
    Rhodium
(Chief Bee)
04-21-01 14:46
No 185704
       Re: Help to make 1,5-dibromopentane (Method). for PCP  Bookmark   

Check out www.orgsyn.org - there should be several ether and alcohol brominations in Organic Synthesis.

http://rhodium.lycaeum.org