08-30-01 04:33
No 208479
Check out
Inorganica Chimica Acta, Volumes 300-302, 20 April 2000, Pages 693-697
Mescaline synthesis via tricarbonyl (6-1,2,3-trimethoxybenzene)chromium complex,
looks interesting......
(Hive Addict)
08-30-01 05:29
No 208495
is that in english?
(Hive Bee)
10-18-01 22:20
No 226374
anyone ever read this?
(Chief Bee)
10-18-01 23:31
No 226400
Yes, I have. The above compound is treated with acetonitrile and BuLi to form 3,4,5-trimethoxyphenylacetonitrile, which is reduced to mescaline. It is not especially practical, but it is a very elegant novel synthesis.
(Hive Bee)
10-19-01 01:17
No 226437
ive been trying to find the most OTC mescaline synthesis. there are many synths floating around here, its a little daunting.
i figured that this one would be not very otc, but im amazed at how many interesting routes there are to this chemical.
(Distinctive Doe)
10-19-01 01:47
No 226467
very elegant novel synthesis
In other words,
difficult and requireing expensive and hard to get reagents
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(Hive Bee)
10-19-01 01:50
No 226471
i know.
im just being a good bee and gathering pollen. plus reminding some bees who might be interested.
(Stranger)
11-09-01 07:36
No 234837
Rho, i know that many people have different opinions, but what is YOUR opinion of the EASIEST synth of (CH3)3-PEA from (CH3)3-Beta nitro styrene. Please help this struggling little girl. Thank you
(Old P2P Cook)
11-09-01 08:14
No 234844
synth of (CH3)3-PEA
What in the heck is this? Trimethylphenethylamine??? I think you should be posting this over in the Newbee Forum!
(Chief Bee)
11-09-01 20:06
No 234908
Xgoddess: If you are referring to mescaline, then I'd suggest reduction of the double bond with NaBH4, followed by Al/Hg reduction of the nitro group. The overall yields approach 60% generally. Details can be found on my page.
(Hive Addict)
11-10-01 00:05
No 234951
Well, there are some molecules, like 4-Me-3,5-MeO-PEA that have been experimented with..
I wonder if anyone has tried 3,4,5-Me-PEA or if anyone has tried 4-Me-3,5-MeO-A. (sorta like DOM, except with a 3-MeO instead of a 2-MeO) Although I suppose since TMA-2 is more active than TMA, the 2,4,5- subsitutition pattern in alpha methyl PEAs is more active than in PEAs (where the 3,4,5- arrangement seems to give the only really active molecules) and my idea of a 4-Me-3,5-MeO-A would be sort of silly.
(Chief Bee)
11-10-01 01:18
No 234972
4-methyl-3,5-dimethoxyphenetylamine has been explored in humans (DESOXY, Pihkal #52, http://leda.lycaeum.org/Documents/PIHKAL
In the extensions and commentary part of the above article, the following can be read:
This is not the first time that oxygen atoms have been removed from the mescaline molecule. Both the 3,5-dideoxymescaline (3,5-dimethyl-4-methoxyphenethylamine) and 3,4,5-trideoxymescaline (also called desoxymescaline in the literature, but really tri-desoxymescaline or 3,4,5-trimethylphenethylamine) have been studied in the cat, and have shown extraordinary pharmacological profiles of CNS action. The trimethyl compound showed behavior that was interpreted as being intense mental turmoil, accompanied by a startling rise in body temperature. The significance is hard to determine, in that LSD gave similar responses in the cat, but mescaline was without effects at all. No human studies have been made on these compounds, just animal studies. But they might prove upon trial in man to be most revealing. They would have to be performed with exceptional care.
The 3-carbon chain amphetamines that correspond to these mescaline look-alikes with one or more methoxy groups replaced with methyl groups, are largely untested and would require independent and novel syntheses. The 3,4,5-trimethylamphetamine is known, and is known to be very hard on experimental cats.
A mescaline analogue with a bromo atom in place of the 4-methoxyl group is an analogue of mescaline in exactly the same way that DOB (a very potent amphetamine) is an analog of TMA-2 (the original trisubstituted amphetamine). This analogue, 3,5-dimethoxy-4-bromoamphetamine, has been found to be a most effective serotonin agonist, and it is a possibility that it could be a most potent phenethylamine. But, as of the present time, it has never been assayed in man.
(Hive Bee)
11-12-01 04:04
No 235724
I have read the paper,
and by using HMPA, and The Harpoon, it makes the methodology laughably sad
(Distinctive Doe)
11-13-01 06:14
No 236126
Those methyl analogs sound SCARY. So who wants to taste test them??
Who ever tastes them can be the entertainment at the next Hive convention.
Don't worry we will have a nice padded room set up for you.
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