12-12-01 09:25
No 246755
Hi!
As always, the wheels just keep on turning inside this bee's head, and Ive started to wonder, with all this talk of 2,3,4,5-Bis-MD-P2P syntheses, Ive wondered about the 2,3,5,6-Bis-MD-P2P version. Its symmetrical and thus better
Jokes aside, I wonder if this is a possible route to such a compound? Although long, can you think of other routes to such compound that dont involve the destruction of premade substitutions on the aromatic ring? I think that is so rude, to rip off the creations of nature, and replace them with your own. Stealers!
Toluene = PhMe
PhMe + HNO3 ==H2SO4==> para-NO2PhMe (nitrotoluene)
para-NO2PhMe + Al ==H2SO4==> 2,5-dihydroxy-1-methylbenzene
As shown here:
../rhodium /quinone
2,5-dihydroxy-1-methylbenzene + Calcium hypochlorite --> 2,5-dihydroxy-1-(dichloromethyl)benzene ==KOH==> 2,5-dihydroxy-benzaldehyde ==NaOH, H2O2, Dakin Reaction==> 1,2,4-trihydroxybenzene
1,2,4-trihydroxybenzene + vinyl chloride --> 2-vinyloxy-benzene-1,4-diol --HEAT--> 5-vinyl-benzene-1,2,4-triol --KMnO4--> 2,4,5-trihydroxy-benzaldehyde --Dakin reaction--> Benzene-1,2,4,5-tetraol
Benzene-1,2,4,5-tetraol + DCM ==PTC==> 1,2,4,5-Bis-Methylenedioxy-Benzene
1,2,4,5-Bis-MD-Benzene + Mn(OOCCH3)3 ==AcOH==> 2,3,5,6-Bis-MD-P2P
Hmm, I can already see a few problems with this, but it was still fun to write! Any comments, maybe some better ideas?
PrimoPyro
Vivent Longtemps la Ruche! STRIKE For President!
(Hive Bee)
12-12-01 14:12
No 246779
Post 245368 (Rhodium: "Any known bis-methylenedioxy compounds?", Chemistry Discourse)
(Hive Addict)
12-12-01 20:53
No 246853
Thats definitely a better way to make it than this. I cant wait for your results hest on the oxidation of hydroquinone.
I thought that thread was on the 2,3,4,5-MD derivative. Damn.
PrimoPyro
Vivent Longtemps la Ruche!
(Hive Bee)
12-12-01 22:38
No 246872
Shit I just like that method to the 2,5 substitution scheme, easy way to make 2C-B or maybe DOB from toluene.....
(Hive Bee)
12-13-01 00:05
No 246895
P.P. Talk with the boos abuth that
(Hive Bee)
12-13-01 17:19
No 247131
What about this : Post No 246184 ?
How do I fix this link?
(Newbee)
12-13-01 17:51
No 247135
enclose the post in square parenthesis Post 246184 (boppesz: "Re: Any known "bis-methylenedioxy" compounds?", Chemistry Discourse)
(Hive Addict)
12-13-01 21:16
No 247198
boppesz:
Yum Yum 
Vivent Longtemps la Ruche!
(Hive Bee)
12-14-01 17:29
No 247509
Did you mean this sarcastic? I know that we can't make a symetrical allylbenzene out of dillapiole, but we can make [2,3][4,5]bismethylenedioxyallylbenzene.
(Hive Bee)
12-14-01 22:49
No 247610
does somebody have the pharmacology info for this comp?
(Chief Bee)
12-14-01 23:23
No 247626
Definitely not, it hasn't been prepared by anyone yet.
(Hive Bee)
12-15-01 00:17
No 247659
I devenitely give it a try when I get dillapiole. But that will take a while because I have to experiment first with the ordinary procedures to get them allright. So maybe I'll not be the most right person to do that, untill you guys like to wait for a year