05-12-02 11:00
No 307685
I require some trifluoromethylpropiophenone and trifluoromethylvalerophenone as precursors for controlled substance analogs. Unfortunately, my textbook told me that direct acylation of benzotrifluoride wouldn't be possible. If you heat a mixture of benzotrifluoride and propionylchloride with aluminum chloride, the result is benzotrichloride and hydrogen fluoride.
Anybody know a useful catalyst for direct acylation ?
(«
»)05-14-02 11:36
No 308459
I don't think direct acylation will work due to what I would guess is the deactivating nature or the triflouromethyl group.
You could form the benzaldehyde first (maybe) and then go with a grignard reaction to get the alcohol which could then be oxidized to the ketone. Just an idea.
I'll hit the library sometime soon and see what I can find.