Vibrating_Lights (Hive Addict)
06-03-02 07:12
No 317069
       Methoxamine  Bookmark   

Looking at the chemical structure of Methoxamine is it concieveable then that the 2-amino-1-(2,5dimethoxyphenyl)-1-propanol could be reduced via HI to the amphetamine. or any of the various ephedrine pathways.
VL_ 		 
 
 
 
    PrimoPyro
(Hive Prodigy)
06-03-02 07:16
No 317070
       I believe this has been brought up before, and it ...  Bookmark   

I believe this has been brought up before, and it was concluded that, at least with the HI reduction, the methoxy groups would be torn to pieces. 		 
 
 
 
    PolytheneSam
(Master Searcher)
06-03-02 07:29
No 317076
       How about this? Post 178931 us 2243295  Bookmark   

How about this?  Post 178931 (PolytheneSam: "PPA --> meth this easy?", Chemistry Discourse)
Patent US2243295
http://www.geocities.com/dritte123/PSPF.html
The hardest thing to explain is the obvious 		 
 
 
 
    obia
(Stranger)
06-05-02 01:11
No 317649
       things from methoxamine  Bookmark   

should reduce with cat h2 and a small amount of phosphoric acid to 2,5 dma. the phosphoric acid shouldn't cleave the meos.
it could be brominated then oxidised to dob (cath)inone. there might be a problem with the hydroxy group being chewed up. I would guess that dob-inone would be have a few unwanted cardiovascular effects though

or it could be turned into an aminorex derivative, possibly with a halo 4 substituent added in prior to ring closure.

I guess though that economics dictate it isn't going to be a good starting material.