01-03-03 09:53
No 395069
What solvents are inert towards CaC2? More specifically, one that acetamide would be fairly soluble in.
It is seductive, way too seductive. -Eleusis
(Hive Addict)
01-03-03 09:55
No 395070
What does this has to do with: Novel synthetic routes to psychoactive materials
"Turn on, Tune in and Drop Out"
(Hive Addict)
01-03-03 10:14
No 395075
Well, I didn't really mention it in the question but I was asking this so that I could start forming a procedure for dehydrating acetamide to acetonitrile. So if anybody has thoughts on that too, I'd like to hear them.
It is seductive, way too seductive. -Eleusis
(Chief Bee)
01-03-03 10:45
No 395088
You want a solvent not containing any acidic hydrogens or other functional groups sensitive to bases. Such solvents include hydrocarbons (like hexane/toluene) and ethers (THF/Et2O).
Chlorinated hydrocarbons (DCM, chloroform) might react, so don't use them just to be safe. Esters, alcohols and ketones and any solvents not properly dried are directly unsuitable.
(Newbee)
01-03-03 18:07
No 395154
Would CaC2 dissolve in benzaldehyde, forming (after acidification) 1,4-diphenyl-1,4-dihydroxy-2-butyne?
CaC2 + 2Ph-CHO -> Ph-C(OH)-C---C-C(OH)-Ph
(Chief Bee)
01-03-03 18:43
No 395160
According to what mechanism?
(Newbee)
01-03-03 19:56
No 395173
Just a thought... C22- being such a strong base, that it would add to the carbonyl and making a hydroxy... SN2 basically... Well... a nucleophile attack anyway...
If CaC2 won't dissolve in benzaldehyde, then this wouldn't work. But perhaps with another solvent...?
(Newbee)
01-12-03 05:24
No 397396
Anybody...any knowledge about this...?
(Master Searcher)
01-12-03 16:44
No 397550
Maybe you could heat acetamide and CaC2 together without a solvent. Try a small amount in a test tube. You could connect a one hole rubber stopper and 90 degree piece of glass tubing to the test tube and then connect a condenser to it and see if you can distill off any CH3CN.
http://www.geocities.com/dritte123/PSPF.
The hardest thing to explain is the obvious