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Rhodium (Chief Bee) 07-17-03 16:28 No 448125 |
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Eugenol to Homogenol (3-EtO-4-OH-Allylbenzene) (Rated as: excellent) |
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Synthesis of 3-Ethoxy-4-Hydroxy-Allylbenzene from 3-Methoxy-4-Hydroxy-Allylbenzene (Eugenol) Nenokischi Hirao Bull. Chem. Soc. Japan 11, 179-184 (1936) (../rhodium/pdf /eugenol2homo I found this article in an abstract database, where they only told that it contained a procedure for converting the Methoxy group of Eugenol to the Ethoxy homolog (called Homogenol by the authors), with no further details given. Great, I thought, then it most definitely contains a procedure for demethylation of eugenol to form 3,4-Dihydroxyallylbenzene (5-allylpyrocatechol), an excellent precursor to safrole. However, when I actually found the article, I saw that it contained a rather byzantine route for the insertion of that extra CH2 group. ![]() However, the article contains some rather interesting chemistry anyway, and various compounds which very likely can be used as precursors to other substances than safrole. |
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