05-11-00 20:39
No 3107
Hello, new to THE HIVE. One question if I may, where can I find the steps tp preparing the Grignard reagent using, specifically, cyclopentyl bromide and magnesium. I have searched for days in Vogels, but I have not been able to find this particular preparation in enough detail, inc. glass and chem req'd. Thank you for your help.
(Chief Bee)
05-12-00 10:42
No 3353
All grignard reagents are made in the same fashion, just substitute cyclopentyl bromide with the alkyl halide used in any prep in Vogel's.
http://rhodium.lycaeum.org
(Stranger)
05-12-00 18:28
No 3522
Yup, just add yer alkyl halide to some ether, then add Mg metal in excess (slowly, exothermic), and voila!
(Stranger)
05-14-00 17:04
No 4205
Thankyou Rhodium and zephler. It's funny, after posting my request, I looked at the whole Grignard thing again (in Vogel's), and it clicked, some of these things (organic chemistry) only LOOK difficult due to the chemical names and procedures. As a Chef [food] I should have known. Thankyou for your help and prompt replies.
(Stranger)
05-14-00 22:35
No 4343
Chemists hide behind big words and phrases so that they sound intelligent, when really its just basic stuff we talk about
(Stranger)
05-17-00 10:01
No 5744
Have anyone ever tryed makeing ephedrine from the grignard reagent phenylmagnesiumbromide and N,N-dimethyl-2-aminoethanal, or isn't the procedure possible. Could you btw syntesise ephedrine in other ways?
Meth~o~xy
(Chief Bee)
05-17-00 14:04
No 5843
That reaction would produce N-methyl-ephedrine, which would be reduced to N,N-dimethyl-amphetamine, which is not active.
http://rhodium.lycaeum.org