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dormouse
(Member) 04-19-00 11:47 No 122753 |
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A synthetic challenge: THIQ chemistry | Bookmark | |||||
Author Topic: A synthetic challenge: THIQ chemistry drone 342 Member posted 09-14-98 08:36 PM ---------------------------------------- As most of you probobly know, tetrahydroisoquinolines are a group of chemicals that haven't been given as much study as they ought to from an entheogenic standpoint. Many of the naturally occuring analogs are found within the human body, and have a pharmacology far different from anything else encountered. From a pharmacological point of view, they are particularily fascinating in the sense that they are a sort of chemical overlap of the opiates and the PEA's. Here's my query: How would one produce them without using PEA's? I've found several efficient routes that have PEA's as intermediates, but how would one accomplish the synthesis of THIQ's without going through that particular class of chemicals? -drone #342 Pomeranz-Fritsch synth reacts a benzaldehyde w/ aminoacetaldehyde diethyl acetal to give an imine. Imine is cyclized w/ H2SO4 to get quinoline. Yields variable, need e- releasing subst. on benzaldehyde. Have any targets in mind? Rho: That amino propriophenone above would give a quinoline rather than isoquinoline.
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