Antoncho
(Stranger) 12-03-00 01:42 No 72147 |
Indolylacetic to triptophol | Bookmark | ||||||
the idea isn't exactly mine but it was undeservedly forgotten anyway i remember having seen a reference on the hive that stated that refluxing tryptofol with dimethylamine/Raney Ni in alc. soln gives DMT in good yields. no further details were given, but i think that sentence already contains everything one needs exept the rxn time. Keeping in mind that along with the following facts: 1) Raney Ni is easily made by thermal decomposition of Ni oxalate/ formate 2) tryptofol is only one reduction away from indolylacetic acid (heteroauxin - sodium indolylacetate) 3) heteroauxin is freely available from plant supply stores 4) all other DMT synths require LAH that is so fuckin inaccessible to many of us , the following obvious questions arise: 1) what of the following reagents can be used for reducing IAA to tryptofol: a) sodium in EtOH b) Al isopropoxide c) Al amalgam d) tin (II) cloride 2) are there any other simple methods for acid to alcohol reduction? i sincerely hope that i got some of you bees interested Antoncho |
||||||||
ragga (Hive Bee) 12-12-00 16:10 No 74987 |
Re: Indolylacetic to triptophol | Bookmark | ||||||
i'm intrested but have nothing to offer yet. |
||||||||
smiley_boy (Hive Bee) 12-13-00 08:35 No 75151 |
Re: Indolylacetic to triptophol | Bookmark | ||||||
This doesn't quite make sense; where did this idea originate from? What exactly do you mean by 'triptophol'? If its 2-(indole-3-yl)-ethanol, then I seriously doubt it could work that way. Still, indole acetic acid can readily be used as a starting material for producing DMT. By condensing indole-3-yl-acetic acid with dimethylamine, you have 2-(indole-3-yl)-acetic acid dimethyl amide. If you then reduce the amide, you have DMT. This last reduction can be accomplished using a number of different reducing agents. But this is certainly not a new idea. This has been used in the literature, and, has been discussed here before. |
||||||||