Baeocystin / 4-PO-MT , Hive Tryptamine Chemistry


SimVilbel (Stranger) 08-16-01 11:26 No 205168	Baeocystin / 4-PO-MT	Bookmark
	I was wondering...does anybody know much about Baeocystin? I remember a while back reading about p.semilanceata/"Liberty Caps" (which contain about .2%) having a little more "kick" than a normal psilo, as well as a tendency to see mushroom caps.. Does anybody have any experience with isolated/synthetic 4-PO/HO-MT? I am interested to know how the effects may differ from 4-PO/HO-DMT. THE BRAIN: My second favorite organ.



Lilienthal (Moderator) 08-16-01 15:09 No 205228	Re: Baeocystin / 4-PO-MT	Bookmark
	I have no idea about its activity, but I wouldn't expect it to be much different from psilocybin. As for the synthesis I would use the following route: 4-AcO-indole ^__(oxalylchloride, Et₂O)^__> 4-AcO-indolyl-glyoxyl-chloride ^__(methyl-benzyl amine)^__> 4-AcO-indolyl-glyoxyl-methyl-benzyl amide ^__(LiAlH₄, THF)^__> 4-OH-methyl-benzyl-tryptamine ^__(tetrabenzyl-pyrophosphat, BuLi)^__> dibenzyl-phosphoryloxy- / monobenzyl-phosphoryloxy-methyl-benzyl-tryptamine ^__(H₂, Pd/C, rt, rp, 24 h)^__> baeocystin The yields should be good for every step of this sequence. And I wouldn't attempt the 'Brenneisen' route. The 4-OH-methyl-benzyl-tryptamine can be acetylated before debenzylation to yield 4-acetoxy-methyl-tryptamine.