psycosmo (Stranger)
08-30-01 04:28
No 208477
      4-HO dipt, aldehyde adapthions, psilocin metabolic  Bookmark   

Was reading an old 60's article about the metabolic pathway for psilocin synthesis, and it hypothesized that Does anyone know if the tryptamine + formaldehyde + reducing agent DMT synth can be adapted to use other aldehydes to make other tryptamines?
the Hydroxy group is added after decarboxylation ot tryptophan and nn dimethylation. If there is a stability problem with 4-Ho tryptamine ore indole this might solve it.
Perhapse 4-HO DIPT could be made by as follows

Tryptamine + isopropyl aldehyde -----> DIPT
DIPT+????? -------->4-HO DIPT
 
 
 
 
    terbium
(Hive Addict)
08-30-01 06:12
No 208502
      Re: 4-HO dipt, aldehyde adapthions, psilocin metabolic  Bookmark   


isopropyl aldehyde



That stuff is quite rare and hard to obtain.

 
 
 
 
    meme
(Stranger)
08-30-01 22:32
No 208734
      Re: 4-HO dipt, aldehyde adapthions, psilocin metabolic  Bookmark   

If its relevent I found isopropyl aldehyde for sale from several major chemical suppliers ("FOUND 10 suppliers selling 10 products")

Today is opposites day.  Everything I say, I mean the opposite.
 
 
 
 
    Rhodium
(Chief Bee)
08-30-01 23:18
No 208756
      Re: 4-HO dipt, aldehyde adapthions, psilocin metabolic  Bookmark   

This is the only google hit for isopropylaldehyde: http://ntp-server.niehs.nih.gov/htdocs/Chem_H&S/NTP_Chem7/Radian78-84-2.html

And it seems like it would only introduce a tert-butyl group when used in reductive amination...
 
 
 
 
    terbium
(Hive Addict)
08-31-01 03:34
No 208828
      Re: 4-HO dipt, aldehyde adapthions, psilocin metabolic  Bookmark   

I should have put a wink at the end of my sentence. My guess is that when he says "isopropyl aldehyde", what he really means is acetone.