03-12-02 07:45
No 281300
Yep, folks, another theoretcal DMT post
.This one with some refs
.OK, some hunting around during spring break led me here:
Indole + CH2O + Dimethylamine __> gramine at 80%
(H.R. Snyder, C.W. Smith, and J.H Stewert, J. Amer. Chem. Soc., 66. 200 (1944).)
Indole + CH3CH0 + isopropylamine __> n-isopropyl tryptamine with a 39-60% yield
(H.R. Snyder and D.S. Matteson, J. Amer. Chem. Soc., 79, 2217 (1957) )
So, Does anyone see a problem, beside yield, with
indole + acetaldehyde + dma __> DMT ?
Indole and dimethylamine are very easily acquired.
Acetaldehyde not too hard, either.
Alanine yields acetaldehyde (25-35%), if heated in quinoline, n,n-dimethoxy-p-toluidine, or aniline, the latter of which produces the Schiff base, and must be hydrolized. Not the best way to go about it, though, IMVHO.
(A. Schonberg [i]et al., J. Chem. Soc., 58, 2430 (1936)
Acetaldehyde can also be produced from ethylene
ethylene + PdCl2 + H2O__> acetaldehyde + Pd + HCl
"Acetaldehyde is obtained from ethylene in excellent yield, and this is the most attractive method of industrial synthesis since the metallic palladium formed in the reaction can be regenerated in atmostpheric oxygen" (Weygand 316)
Weygand & Hilgetag. Preperative Organic Chemestry, John Wiley and Sons. New York, 1972.
No barbed wire can cage a bee.
(Chief Bee)
03-12-02 10:05
No 281342
Acetaldehyde does not form tryptamines with indole/dimethylamine, but instead 3-Indolyl-CH(CH3)-CH2-N(CH3)2, gramine with a methyl group sticking out from the carbon atom between the indole 3-position and the amine. In the document ../rhodium /it-290.
-alkyltryptamines.
(Hive Prodigy)
03-12-02 20:28
No 281725
The simplest way to synthesize ethanal is by the oxidation of ethanol, a highly abundant, nonsuspicious laboratory solvent and human intoxicant.
Vivent Longtemps La Ruche!
(Hive Bee)
03-25-02 14:13
No 287771
Could one use 5-meotryptamine (Mexamine) to produce to 5meo analogue of Gramine?
No barbed wire can cage a bee.
(Chief Bee)
03-25-02 23:49
No 288002
No, that is not easily done. Mexamine has a -CH2CH2NH2 side chain on the indole nucleus, while gramines have a -CH2-N(CH3)2 side chain. Chain shortening is not easy. Why would you want to do that? Use mexamine as a starting point for a 5-MeO-AMT derivative?
(Hive Bee)
03-26-02 07:30
No 288118
OK, new rule for meme, I'm not to post until I have writtin out my question/post in full and debugged it.
Of course that won't work. But you are correct in your presumptions of my question.
So if I started from 5meo indole, through the gramine derivitive, I could end up with 5meo amt analogues, right?
And following the routes in TiHKAL for NET, and NiPT, starting with Mexamine, I could produce the n-alkylated, 5meo analogues, right?
No barbed wire can cage a bee.
(Chief Bee)
03-26-02 11:04
No 288169
Yes, you can treat 5-MeO-Indole with dimethylamine/formaldehyde to get 5-MeO-Gramine (3-(dimethylaminomethyl)-5-Methoxyindole
(Hive Bee)
04-04-02 01:38
No 292247
Can someone comment on the qualitative effects of 5-Meo-AMT? I know what AMT is like, but the 5-Meo version would probably be much more potent. Still though, why does homeboy online charge $400/g? WTF? What would make it worth that (considering virtually all the other shit is in the $125 range)?
We need new drugs.
(Chief Bee)
04-04-02 02:48
No 292265
I guess the potency makes for the higher price. People like that actually charge you per dose, not per gram.
(Hive Bee)
04-04-02 13:08
No 292432
5meoamt=2$ per dose
AMT=over 5$ per dose
(Hive Bee)
04-06-02 20:28
No 293497
I see ...well I have experience with neither, but have tried 5-Meo-DMT as well as nn-DMT and even though the 5-Meo-DMT is more potent as expected of a 5-Methoxy, it doesn't seem as intense, still mind blowing, but different. Like it didn't completely shut down ALL sensory input, some but not all. More like K. There's nothing like taking a hugh hit of DMT and going into the depths of sensory deprivation elf land.
We need new drugs.