pHarmacist (Hive Addict) 01-30-03 16:47 No 402816				Cobalt-Catalyzed Total Synthesis of (±)-LSD (Rated as: excellent)	Bookmark
						Abstract: Cocyclization of 4-ethynyl-3-indoleacetonitriles with alkynes in the presence of CpCo(CO)2 gives rise to the ergoline derivatives 6-9, two of which were transformed into racemic lysergene and LSD, respectively. See full-text at: http://pharmacist8.tripod.com/ergot.pdf Reference: Synlett 1994; 487-489 Accept No Imitations, There Can Only Bee One; www.the-hive.ws
		YourMomma7111 (Stranger) 02-03-03 08:35 No 404006				That paper is elegant & beautiful!	Bookmark
						Note that, in conversion from compound 9 to compound 10, one could substitute CF3SO3Et in THF at O degrees Celsius and end up with ETH-LAD (alkyl N-ethylated LSD-025) instead of LSD, which is a much dirtier drug than the former, although on a microgram to microgram scale the two are of about equipotentcies.
		EtHeRpEeKeR 02-11-03 02:52				Yessiree, went right over my head, (Rated as: off-topic)	Bookmark