L42L
(Stranger) 02-18-03 20:35 No 409482 |
?'s acetonitrile synth? | Bookmark | ||||||
Saw this on the bathroom wall in the grout; gramine methosulfate ->NaCN->I-3-acetonitrile. Can some bee tell me about the gramine methosulfate. To the point, how does one get from indole or gramine to gramine methosulfate. Thanks Beez lurk |
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Rhodium (Chief Bee) 02-18-03 21:23 No 409501 |
Gramine Methosulfate | Bookmark | ||||||
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L42L (Stranger) 02-19-03 00:06 No 409557 |
Cool! | Bookmark | ||||||
Neat-o! This might be as simple as I hoped. Thanks for your response, Rhod. Here's the dirt; A solution of gramine methosulfate (30.0g, .10 mol) and NaCN (15.0g, 0.30 mol) in water (300ml) was heated to 65-70 C for one hour. A colurless oil separated as the reaction proceeded. The solution was cooled and saturated with Na2SO4 and extracted with ethyl ether (400ml). The ether was removed in vacuo and the residue purified by high vacuum distillation to give the product in 94% yield. Sit on it Potzee. On my way out of his office the Fonz stuck his thumbs up and said, "J. Thesing and F Schulde. Cem. Ber. 85, 324 (1952)" He wouldn’t say if that’s who scrawled it in the grout of not. Sooooo... Can some bee direct me to the nearest dimethyl sulfate synth, sure seems easy. Did a quick search and didn’t find much, just a thread entitled: Trimethyl phosphate methylation of 4-alkyl1,4-DHOB Comments are appreciated, thanks bees ! lurk |
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Rhodium (Chief Bee) 02-19-03 00:52 No 409568 |
How's your spelling? | Bookmark | ||||||
Do you use the same search engine as I do? With TFSE at https://www.the-hive.ws/forum/searchx.pl |
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Rhodium (Chief Bee) 02-20-03 18:01 No 410166 |
Tryptamine & IAA via a Gramine quaternary salt (Rated as: excellent) |
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Besides, the structure of gramine methosulfate is actually drawn in the article you referenced: Notiz über die präparative Darstellung von Heteroauxin und Tryptamin Jan Thesing & Felix Schülde Chem. Ber. 85, 324-327 (1952) (../rhodium/pdf /heteroauxin. |
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