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pHarmacist (Hive Addict) 04-27-03 06:01 No 429742 |
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SAR: Ring-Substituted N,N-Dialkyltryptamines (Rated as: excellent) |
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SAR Relationships in Potentially Hallucinogenic N,N-Dialkyltryptamines Substituted in the Benzene Moiety Toni B. Kline, Frederick Benington, Richard D. Morin, John M. Beaton J. Med. Chem.; 1982; 25(8); 908-913. A series of N,N-dialkyltryptamines with methylthio or methylenedioxy substituents in the 4, 5, and 6 positions and methyl or isopropyl on the side-chain nitrogen has been synthesized. The behavioral pharmacology of these compounds showed them to possess Bovet-Gatti profiles characteristic of hallucinogens, and the 5-methylthio congener was the most potent. Binding studies a t [3H]LSD and [3H]5-HT sites demonstrated that no single structural feature correlated with binding or behavioral changes and suggest a complex mode of action for these potential hallucinogenic agents. Full-Text: ![]() Accept No Imitations, There Can Only Bee One; www.the-hive.ws |
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Rhodium (Chief Bee) 05-21-04 10:05 No 508621 |
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(N-Cyclopropyl-) 5,6-Methylenedioxytryptamines (Rated as: excellent) |
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Synthesis and Characterization of 5H-1,3-Dioxolo[4,5-f]indoleethylamines Douglas B. Grotjahn J. Heterocyclic Chem. 20, 1031-1036 (1983) (../rhodium/pdf /methylenedio Abstract Twelve new N,N-dialkylated-5,6-methylenedioxytrypta The Hive - Clandestine Chemists Without Borders |
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Rhodium (Chief Bee) 05-30-04 14:21 No 510378 |
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Abramovitch Tryptamine Syntheses (Rated as: excellent) |
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Tryptamines, Carbolines, and Related Compounds. Part II. A Convenient Synthesis of Tryptamines and β-Carbolines. R. A. Abramovitch and D. Shapiro J. Chem. Soc. 4589-4592 (1956) (../rhodium/pdf /tryptamines. Abstract 2,3-Dioxopiperidine 3-phenylhydrazone was cyclised under acid conditions to 1,2,3,4-tetrahydro-1-oxo-β-carbolin ____ ___ __ _ Tryptamines, Carbolines, and Related Compounds. Part III. 1-Methyl- and 1,N-Dimethyl-tryptamines R. A. Abramovitch J. Chem. Soc. 4593-4602 (1956) (../rhodium/pdf /tryptamines. Abstract The scope of the synthesis of tryptamines from 1,2,3,4-tetrahydro-1-oxo-β-carbolin The Hive - Clandestine Chemists Without Borders |
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