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pHarmacist
(Hive Addict) 04-27-03 06:27 No 429746 |
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Synth. and Pharm. of Some Hydroxylated Tryptamines | Bookmark | |||||
Synthesis and Pharmacology of Some Hydroxylated Tryptamines Robert G. Taborsky, Peter Delvigs, Djuro Palaic, Merlin Bumpus; J. Med. Chem.; 1967; 10(3); 403-407. ____ ___ __ _ Full-Text: http://pharmacist8.tripod.com/OH-trypt.p Accept No Imitations, There Can Only Bee One; www.the-hive.ws |
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Chimimanie (Hive Bee) 04-27-03 08:16 No 429758 |
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Nice. I have also a paper describing the ... | Bookmark | |||||
Nice. I have also a paper describing the synthesis of 6-OH-5-MeO-DMT from vanillin as well as the much interesting 4-OH-5-MeO-DMT from o-vanillin. This 5-Methoxy-psylocin should bee VERY interesting ![]() Unrelated but semi-related anyway is that I have another paper which describe the synthesis of 5-MeO-mono-N-alkyl-tryptamine. In tihkal#49 http://www.erowid.org/library/books_onli My two papers are Bull. Soc. Chim. France (1965), (5), 1411-17 and 1417-1423, from the lab of Mr Julia. I could not stop thinking of the potential of this 5-MeO-psylocin ![]() |
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Lilienthal (Moderator) 04-27-03 09:03 No 429766 |
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Sorry, but I don't expect the ... | Bookmark | |||||
Sorry, but I don't expect the 5-MeO-4-OH-tryptamines to be psychedelic. The 5-MeO-4-F-tryptamines are binding preferentially to the 5-HT1A receptor (Paper from Nichols' lab). The bonding to the 4-OH is probably from a receptor residue over the indole-5-position, which is blocked by the 5-MeO. Additionally the 4-substituent moves the methyl of the 5-MeO into that direction due to steric interactions. |
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Chimimanie (Hive Bee) 04-27-03 10:32 No 429778 |
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Mhh, it would be sad :-( But anyway, there is... | Bookmark | |||||
Mhh, it would be sad ![]() But anyway, there is a little pharmacological data in the text, the full pharmacology is in another paper I dont have yet. In the rabbit hyperthermia (research of psychotomimetic action) test of the 5-MeO-4-OH, 5-MeO-6-OH and 7-MeO-6-OH tryptamines, they say that only the 4-benzyloxy-5-MeO DMT, 6-OH-5-MeO DMT and 6-OH-5-MeO-DET are active ![]() But they say also that they are not mimetic- (nor anti- BTW) of the serotonin in the rat uterus test. ![]() And that 7-MeO-6-benyloxy DMT has a stimulating action. As 4-benzyloxy-5-MeO-DMT is at least active in the rabbit, I think the compound should bee researched, and tasted and then we will know. The full pharmacological article should be very useful in a first time too. |
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