(Chief Bee)
05-11-03 20:26
No 432651
(Rated as: excellent)
Microwave Assisted Synthesis of Melatonin
Synthetic Communications Vol. 33, No. 5, pp. 741–747 (2003) (../rhodium/pdf /melatonin.mi
Abstract
Melatonin was prepared from phthalimide by N- and C-alkylation, cyclization, hydrolytic, decarboxylation, and acetylation. The four-pot reactions were carried out on microwave irradiation in good yield with short time.
(Hive and HyperLab Bee)
05-12-03 20:54
No 432831
Ok, could anybody explain reaction step from 2 to 3, something rather fishy there. (I would believe in Japp-Klingeman reaction , but then it use diazonium salt, not arylhydrazine - yet another example of "not very accurate" research paper?)