sushitake
(Stranger) 09-08-03 18:07 No 457808 |
analgesic tryptamine | |||||||
this tryptamine is supposed to have analgesic activity similiar to morphine...I have found relatively little info on it and recieved no responses from suppliers of research chemicals on the availability of the product, any of you bees know anything? about N,N',3-trimethyl-5-hydroxytryptamine? it would seem a good suspect for synthesis for supplying research chemical suppliers no? |
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Vitus_Verdegast (Hive Bee) 09-08-03 18:59 No 457819 |
analgesic tryptamines | |||||||
Can you provide a reference for this? I did a quick search on your compound but came up with nothing, except this paper on analgesic tryptamines:
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Vitus_Verdegast (Hive Bee) 09-08-03 19:03 No 457820 |
N,N'-dicarbonyltryptamines | |||||||
This could also be very interesting:
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Lilienthal (Moderator) 09-09-03 01:22 No 457876 |
There can't be anything like ... | |||||||
There can't be anything like "N,N',3-trimethyl-5-hydroxytryptami |
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sushitake (Stranger) 09-09-03 14:33 No 457975 |
source info | |||||||
Sorry I didnt include this in the first place. Its in one article titled"future synthetic drugs of abuse"by Donald E Cooper, who I think is a DEA chemist. anyway the article mentions shulgin in the preceding paragraph, in re-reading the paper I realize that this compound may not be researched or mentioned by A.Shulgin. the web address came up as WWW.a1b2c3.com/drugs/desi02b.htm I have very limited chemical knowledge,so I really couldnt say if this chemical is possible or in existance anywhere. I think this site is a DEA website so some might want to know that before accessing! Tryptophan has some analgesic qualites, as does serotonin, ANd I remember hearing of a tryptamine in either Pihkal or Tihkal that helps opiate withdrawl, and was being sold as an ecstacy rip-off on the street, before being scheduled, both my copies are on loan so I have no page #'s for it. Perhaps this older paperis flawed in some way, or maybe the chemical work was found to be wrong? Its strange that there are no other reports on it on the internet, or maybe it is held by a private source? Any chemists that dispute the possibility of this compound speak up! The mention of the compound is in part 3 of 3 under the analgesic section. thanks for your time as I have asked around on this for awhile now with no luck. |
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longimanus (Stranger) 09-10-03 06:19 No 458170 |
sushitake has a little mistake. | |||||||
Sushitake has a little mistake. N,N`,3-trimethyl-5-hydroxytryptamine is not the compound mentioned in the text. According to Cooper " There has been discovered one compound which may be of minor interest in that it is an analgesic with potency similar to morphine and can be described as a ring condensation product of N,N`,3-trimethyl-5-hydroxytryptamine (Brossi 1985)." I`ve found this article in Erowid, Rhodium and www.a1b2c3.com and the only difference between the three texts is that in the Erowid variant there is "(compound 46, Figure 14)" in front of "(Brossi 1985)".And since there doesn`t exist N,N`,3-trimethyl-5-hydroxytryptamine I`m dying to see Figure 14. |
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sushitake (Stranger) 09-10-03 13:48 No 458224 |
thanks | |||||||
thanks for the clarification! glad I joined this forum, so its a product of the compound mentioned, and that product is listed in some text by Brossi, but I havnt been able to find the diagrams listed when running searches? Has anyone else? |
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Bwiti (PVC-Analog Taste-Tester) 09-11-03 00:11 No 458339 |
What If.. | |||||||
In Patent US3444174, example 1, I wonder what would be created if something easier to work with, such as diethylamine, is used in place of the ammonia? Maybe it would have analgesic properties? Love my country, fear my government. |
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longimanus (Stranger) 09-11-03 13:10 No 458452 |
eseroline (aka Cooper is NOT a chemist !!! ) (Rated as: use the [medline] tag!) |
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N,N`,3-trimethyl-5-hydroxytryptamine does NOT exist. But 1,3-dimethyl-3-(2-methylaminoethyl)-2,3- And Cooper don`t see any difference!?! I searched Medline for the Brossi`s article and found the following: Further explorations on unnatural alkaloids Bossi A. J Nat Prod 1985 Nov-Dec 48:878-93 Medline (PMID=86142792) accompanied with the abstract below: (+/-)-N1-noreseroline-O-methyl-eth What I know about physostigmine is that it`s an agonist of muscarine and respectively - antagonist of atropine. And then I found the information below: Physostigmine (eserine),C 15 H 21 N 3 O 2 , MW 275.3, CAS 57-47-6, MI 13: 7469, crystaline solid, soluble in chloroform, toxic - forms a carbamylated enzyme complex with acethylcholinesterase that degrades slowly. Crosses blood-brain barrier. (-)-Eseroline.fumarate, C 13 H 18 N 2 O.C 4 H 4 O 4 , MW 218.3 . 116.1, CAS 104015-29-4, white solid, soluble in water or DMSO, slightly soluble in MeOH, metabolite of physostigmine (eserine), potent analgesic. References: Medline (PMID=6293841) Medline (PMID=7092918) Medline (PMID=2858526) So...the analgesic "tryptamine" is actually eseroline. The price of (-)-eseroline fumarate is around 50euro/10mg or 170 euro/50mg and the price of physostigmine is 25euro/100mg (bioresearch grade). Hmm...interesting. |
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sushitake (Stranger) 09-11-03 23:09 No 458556 |
that is great. | |||||||
nice, thanks for the info.So there were some printed errors? if n,n',trimethoxy-hydroxytryptamine doesnt exist why was it listed in this document?I am now going to read up on these substances, thanks agian. opiophile |
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Lilienthal (Moderator) 09-12-03 00:58 No 458582 |
N,N',O-trimetyl-5-hydroxytryptamine would be... | |||||||
N,N',O-trimetyl-5-hydroxytryptamine would be 5-MeO-DMT. |
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longimanus (Stranger) 09-12-03 06:56 No 458659 |
more eseroline | |||||||
Below are some articles about eseroline: Pharmacology: Medline (PMID=91068238) it kills brain cells! Medline (PMID=91334549) Medline (PMID=82231462) Medline (PMID=89211823) Medline (PMID=87065740) Medline (PMID=93209316) Medline (PMID=81185784) Medline (PMID=84179927) Medline (PMID=82014213) Medline (PMID=98369748) Medline (PMID=81122677) Medline (PMID=80074451) Synthesis: Medline (PMID=98296296) Similar to eseroline: Medline (PMID=92277090) There is also an article I couldn`t find: `A Formal Synthesis of (+)-Eseroline via an Aza-oxy-Cope Rearrangement` Santos,PF; Almeida,PS; Lobo,AM;Prabhakar,S.; Heterocycles, 2001, 55, 1029-1043. http://www.cpdd.vcu.edu/DEC/acrobat/DEC1 And, Lilienthal, do you mean the toad, mimosa, etc. 5-MeO-DMT or...cuz I think that "N`" refers to the indole nitrogen?!? |
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Lilienthal (Moderator) 09-12-03 08:00 No 458668 |
N stands for amine nitrogens, like in ... | |||||||
N stands for amine nitrogens, like in N,N'-dimethyl-tryptamine. The indole-N is position 1 and this nitrogen is not an amine. |
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sushitake (Stranger) 09-12-03 11:34 No 458707 |
calabar bean | |||||||
im sure you guys noticed that physostigmine can be extracted from the calabar bean. Man this bean is toxic!! nicknamed the "ordeal bean" this plant appears to have been used for murder and torture. I noticed commercial eye-drop preperations of both calabar bean extract and physostigmine for sale on the net. Maybe the metabolite (-)-eseroline is less toxic than physostigmine?.appears to be used for alzhiemers now also. opiophile |
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longimanus (Stranger) 09-12-03 12:02 No 458716 |
and what about the "`" ? | |||||||
So, what does "`" mean? "N`" stands for second substituted nitrogen atom. For example N,N`-dimethylehtyleneurea = 1,3-dimethyl-2-imidazolidinone. And which is the second nitrogen in tryptamine? But we are not talking about tryptamine. Look at the structure of eseroline. N,N`,3-trimethyl-5-hydroxytryptamine doesn`t exist. Cooper means 1,3-dimethyl-3-(2-mehtylaminoethyl)-2,3- It`s more toxic. Read Medline (PMID=91068238): Eseroline was comparatively more toxic than the parent compound, physostigmine. You can buy eye-drops, hydrolize physostigmine to eseroline and...kill someone slowly. Search for derivates: SAR Medline (PMID=81122677) Akuammine Medline (PMID=92277090) |
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Lilienthal (Moderator) 09-12-03 13:21 No 458727 |
It just means that both alkyl residues are put | |||||||
It just means that both alkyl residues are put on the only free amino positions available - the same nitrogen. It's like a numbering of free amine positions. N,N'-dimethyl-tryptamine or N,N-dimethyl-tryptamine is DMT. Please continue in the Newbee forum . |
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longimanus (Stranger) 09-13-03 01:46 No 458839 |
"`" | |||||||
Example: http://www.orgsyn.org/orgsyn/orgsyn/prep Let`s stop this! The theme of the thread is analgesic tryptamine but we`re arguing about nomenclature. respectfully, longimanus |
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xeno_tropic (Newbee) 09-22-03 13:19 No 460436 |
analgesic tryptamine | |||||||
Yes, please do post a ref! |
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