Rhodium (Chief Bee) 07-12-04 22:46 No 518956				Analgesic N-acyl-Melatonins?
						Anyone know anything about these? To what extent are they analgesic, and by what mechanism? Synthesis and analgesic activity of N-(N-acetyl-L-amino-acyl)-5-methoxytryptamines. Dongmei H, Chao W, Ming Z, Shiqi P., Prep Biochem Biotechnol. 30(1), 39-47 (2000) Medline (PMID=10701451) Abstract 5-Methoxytryptamine was acylated with N-acetyl-L-amino acids to give rise the corresponding N-(N-acetyl-L-amino acyl)-5-methoxytryptamines. The analgesic activity was evaluated by the tail flick test. Among the 6 compounds, the analgesic potency of N-(N-acetyl-tryptophanyl)-5-methoxytryptamine (5e) and N-(N-acetyl-glycyl)-5-methoxytryptamine (5a) are much more potent than that of melatonin. The Hive - Clandestine Chemists Without Borders
		Saddam_Hussein (Newbee) 07-14-04 23:43 No 519437				Also
						Of possible interest as well: Medline (PMID=10919562) Synthesis and analgesic activity of N,N'-dicarbonyltryptamines. Dongmei H, Chao W, Ming Z, Shiqi P. 5-Methoxytryptamine and L-tryptophan methyl ester were acylated with malonic acid, dimethyl malonate, or succinic anhydride to produce the corresponding N,N'-dicarbonyltryptamine derivatives. The analgesic activity was evaluated by the tail flick test. All of the compounds exhibited desirable analgesic potency. This result is consistent with that of N-(N-acetyl-L-tryptophanyl)-5-methoxytryptamine and confirmed that introducing substituted tryptamine into the amide chain of melatonin does enhance analgesic potency. President of the Iraqi Chemical Weapons of Mass Destruction Development Society