Chromic
(Hive Addict) 02-23-02 21:29 No 272587 |
Reducing aryl alkyl carbonyls | Bookmark | ||||||
Well, in my studies I crossed a reduction of aryl alkyl carbonyls (maybe best called benzylic carbonyls?) to aryl akyls, which sort of surprised me because it used H2/Pd giving the same ends as the Wolf-Kishner which has been talked about in Post 172398 (rubberneck: "Wolff-Kishner reduction", Stimulants) but with nearly 100% yields. Anyone tried this on methcathinone or Wellbutrin? |
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Sunlight (Pioneer Researcher) 02-23-02 22:29 No 272625 |
Re: Reducing aryl alkyl carbonyls | Bookmark | ||||||
CTH reduces carbonyls too, and seems more accesible. |
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Rhodium (Chief Bee) 02-24-02 04:19 No 272741 |
Re: Reducing aryl alkyl carbonyls | Bookmark | ||||||
True, CTH seems like it is good for almost anything. BTW, the Wolff-Kishner reduction can be carried out in the microwave in 1-2 minutes, I can dig up the ref if you want to. I don't think the Wolff-Kishner reduction works well with vicinal aminoketones (as in methcathinone) though, as they can self-condense to unusable pyrazines under basic conditions. |
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