03-09-02 20:58
No 279942
MOP has heard that DMSO can be used to introduce any chemicals disolved in it into the body simply by contact with the skin. Does anyone know the process which makes DMSO (in particular) so effective at this??
Suicide is man's way of telling God, "You can't fire me—I quit." — Bill Maher, 1995
(Hive Bee)
03-09-02 22:05
No 279960
Not certain but it has something to do with penetrating lipid membranes well I believe, as it is often used in genetic manipulation experiments where DNA is introduced into yeast.
(Newbee)
03-14-02 17:39
No 282733
This should cover all of your questions.
http://www.dmso.org/articles/information
The Ultimate Weapon Can't be controlled, banned or confiscated. Your weapon's your mind.
(Hive Bee)
03-15-02 17:37
No 283211
Been a while since Ochem but I believe it's the shape of the molecule (polarity) that allows it to rapidly cross lipid membranes. Ceps bud used to administer some of his gear via that route and it worked pretty well. Would dissolve the intended dose in dmso, add in a little distilled water then rub the mix onto his inner thigh. Then wrap with plastic wrap and leave it wrapped untill it was absorbed. Ceps never had the patience for this method and never could stand the horrible breath. Man smelled like the guy had been out eating those little green onions that grow in the front yard.
"No I'll tell you what insanity is, insanity is majority rules"
(Hive Bee)
03-19-02 17:36
No 285095
dmso also has potential dangers, such as the introduction of bacterial elements into the body. A good shower and clean clothes are a necessity when using it.
A kid who refused to respect adults
(I'm not Cheesie)
03-19-02 22:11
No 285168
Ya, don't forget to double wrap it!!
Cheeseboy- a whiteboy with soul, like a black guy without soul
May De Source Bee Wit Chu...Always
(Stranger)
03-20-02 06:50
No 285365
AND U CAN TRY THIS WEB ..
NO SOURCES, and NO all-caps posts!
(Hive Addict)
03-20-02 08:01
No 285397
Could DMSO be used as a solvent For low dose compound delivery.
VVL_
(Chief Bee)
03-20-02 12:34
No 285479
Yes, that works with many compounds. UTFSE to find LSD/DMSO references.
(Hive Addict)
03-23-02 22:33
No 287204
I was curious - does dmso manage to carry anything that can be disolved in it through the skin? If not, what determines what can be carried and what can't bee.
Suicide is man's way of telling God, "You can't fire me—I quit." — Bill Maher, 1995
(Chef d'Equippe)
03-24-02 00:48
No 287236
DMSO is the #1 favorite of the CIA for transdermal delivery of chemical incapacitators. Nice little section about it in their training manual.
GODISNOWHERE
Shoot Narcs, Not Drugs
(Newbee)
03-24-02 12:17
No 287371
I happen to have a drug that is from the pharmacy that is transfered through the skin (or something) I don't have it on hand, but it was a no-needle syringe containing about 1/2 ml of a gel substance. It could be rubbed anywhere on the body and took effect within 10 minutes. The funny part was that it contained 50 mg of whatever drug it was. That is the most I have ever heard of being delivered through the skin. Oh, it was for your stomach. If you were getting sick (viral infection to hangovers), this stopped it cold. Will edit when I know what it was.
It was called Prometh. Does anybody know what they use to make it work? (the entry method, not the medicine)
(Hive Bee)
03-25-02 00:32
No 287558
The exact mechanisms involved in the membrane penetrant action of DMSO have yet to be elucidated.
Membrane Penetration
DMSO readily crosses most tissue membranes of lower animals and man.
Employing [35S] DMSO, Kolb et al, evaluated the absorption and distribution of DMSO in lower animals and man. Ten minutes after the cutaneous application in the rat, radioactivity was measured in the blood. In man radioactivity appeared in the blood 5 minutes after cutaneous application. One hour after application of DMSO to the skin, radioactivity could be detected in the bones.
Denko and his associates applied 35S-labeled DMSO to the skin of rats. Within 2 hour a wide range of radioactivity was distributed in all organs studied. The highest values occurred in decreasing order in the following soft tissues; spleen, stomach, lung, vitreous humor, thymus, brain, kidney, sclera, colon, heart, skeletal muscle, skin, liver, aorta, adrenal, lens of eye, and cartilage.
Rammler and Zaffaroni have reviewed the chemical properties of DMSO and suggested that the rapid movement of this molecule through the skin, a protein barrier, depends on a reversible configurational change of the protein occurring when DMSO substitutes for water.
B. Membrane Transport
Nonionized molecules of low molecular wight are transported through the skin with DMSO. Substance of high molecular weight such as insulin do not pass through the skin to any significant extent. Studies in our laboratory have revealed that a 90% concentration of DMSO is optimal for the passage of morphine sulfate dissoved in DMSO.77 It would have been expected that 100% would provide better transport than 90%, and the reason for an optimal effect at 90% DMSO remains unexplained. It is of course well known that 70% alcohol has a higher phenol:water partition coefficient than 100% alcohol.
Elfbaum and Laden conducted an in vitro skin penetration study employing guinea pig skin as the membrane. They concluded that the passage of picrate ion through this membrane in the presence of DMSO was a passive diffusion process which adhered to Fick's first law of diffusion. It is demonstrated by diffusion and isotope studies that the absolute rate constant for the penetration of DMSO was approximately 100 times greater than that for the picrate ion. Thus, the two substances were transferred through the skin independently of each other. The exact mechanisms involved in the membrane penetrant action of DMSO have yet to be elucidated.
Studies on membrane penetration and carrier effect have been carrier effect have been carried out in agriculture, basic biology, animals, and man. In field tests with severely diseased fruit, Keil demonstrated that oxytetracycline satisfactorily controlled bacterial spot in peaches. Control was significantly enhanced by adding DMSO to the antibiotic spray. DMSO was applied to 0.25 and 0.5% with 66 ppm of oxytetracycline. This application gave control of the disease similar to that produced alone by 132 ppm of oxytetracycline and suggested the possibility of diluting the high-priced antibiotic with relatively inexpensive DMSO. There is no good evidence in animals that 0.5% DMSO has significant carrier effects. It could well be that Keil's results were attributable to a carrier effect, but the possibility should always be considered that when DMSO is combined with another substance a new compound results which can then exert a greater or lesser influence on a given process.
Leonard63 studied different concentrations of several water-soluable iron sources applied as foliage sprays to orange and grapefruit trees whose leaves showed visible signs of iron deficiency. The application of iron in DMSO as a spray was followed by a rapid and extensive greening of the leaves, with a higher concentration of chlorophyll.
Amstey and Parkman evaluated the influence of DMSO on the infectivity of viral nucleic acid, an indication of its transmembrane transport. It was found that DMSO enhanced polio RNA infectivity in kidney cells from monkeys. Enhancement occurred with all DMSO concentrations from 5 to 80% and was optimal at 40% DMSO, with a 20-minute absorption period at room temperature. A significant percentage of nucleic acid infection was absorbed within the first 2 minutes.
Cochran and his associates concluded that concentrations of DMSO below 20% did no influence the infectivity of tobacco mosaic virus (TMV) or the viral RNA. With concentrations between 20 and 60% the infectivity of TMV and TMV RNA varied inversely with the DMSO concentration.
Nadel and co-workers suggested that DMSO enhanced the penetration of the infectious agent in experimental leukemia of gunea pigs. Previously Schreck et al. had demonstrated that DMSO was more toxic in vitro to lymphocytic leukemia than to lymphocytes from normal patients.
Djan and Gunberg studied the percutaneous absorption of 17-estradiol dissolved in DMSO in the immature female rat. These steroids were given in aqueous solutions subcutaneously or were applied topically in DMSO. Vaginal and uterine weight increases resulting from estrogen in DMSO administered topically were comparable to results obtained in animals in which the drugs were administered in pure form subcutaneously.
Smith reported that a mixture of DMSO and diptheria toxoid applied frequently to the backs of rabbits causes a reduction of the inflammation produced by the Shick test, indicating that a partial immunity of diphtheria has been produced.
Finney and his associates studied the influence of DMSO and DMSO-hydrogen peroxide on the pig myocardium after acute coronary ligation with subsequent myocardial infaction. The addition of DMSO to a hydrogen peroxide perfusion system fascilitated the difffusion of oxygen into the ischemic myocardium.
Maddock et al. designed experiments to determine the usefulness of DMSO as a carrier for antitumor agents. The agents were dissoved in 85-100% concentrations of DMSO. One of the tumors studied was the L1210 leukemia. Survival time without treatment was appoximately 8 days. The standard method of employing Cytoxan intraperitoneally produced a survival time of 15.5 days. When Cytoxan was applied topically in water, the survival time was 12.6 days, and topical Cytoxan dissolved in DMSO resulted in survival time of 15.3 days.
Spruance recently studied DMSO as a vehicle for topical antiviral agents, concluding that the penetration of acyclovir (ACV) through guinea pigs skin in vitro was markedly greater with DMSO than when ployethylene glycol (PEG) was the vehicle. When 5% ACV in DMSO was compared with 5% ACV in PEG in the treatmental herpes infection in the guinea pig, ACV DMSO was more effective.
The possibility of altering the blood-brain diffusion barrrier with DMSO needs additional exploration. Brink and Stein10 employed [14C]pemoline dissolved in DMSO and injected intraperitoneally into rats. It was found in larger amounts in the brain than was a similar dose given in 0.3% tragacanth suspension. The authors postulated that DMSO resulted in a partial breakdown of the blood-brain diffusion barrier in vitro.
There is conflicting evidence as to whether dimethyl sulfoxide can reversibly open the blood-brain barrier and augment brain uptake of water-soluable compounds, including anticancer agents. To investigate this, 125[-Human serum albumin, horse-radish peroxidase, or the anticancer drug melphalan was administered iv to rats or mice, either alone or in combination with DMSO. DMSO administration did not significantly increase the brain uptake of any of the compounds as compared to control uptakes. These results do not support prior reports that DMSO increases the permeability of water-soluable agents across the blood-brain barrier.
Maibach and Feldmann studied the percutaneous penetration of hydrocortisone and testosterone in DMSO. The authors concluded that there was a threefold increase in dermal penetration by these steroids when they were dissolved in DMSO.
Sulzberger and his co-workers evaluated the penetration of DMSO into human skin employing methylene blue, iodine, and iron dyes as visual tracers. Biopsies showed that the stratum corneum was completely stained with each tracer applied to the skin surface in DMSO. There was little or no staining below this layer. The authors concluded that DMSO carried substances rapidly and deeply into the horny layer and suggested the usefulness of DMSO as a vehicle for therapeutic agents in inflammatory dermatoses and superficial skin infections such as pyodermas.
Perliman and Wolfe demonstrated that allergens of low molecular weight such as penicillin G potassium, mixed in 90% DMSO, were readily carried through intact human skin. Allergens having molecular weights of 3000 or more dissolved in DMSO did not penetrate human skin in these studies. On the other hand, Smith and Hegre101 had previously recorded that antibodies to bovine serum albumin developed when a mixture of DMSO and bovine serum albumin was applied to the skin of rabbits.
Turco and Canada have studied the influence of DMSO on lowering electrical skin resistance in man, In combination with 9% sodium chloride in distilled water, 40% DMSO decreased resistance by 100%. It was postulated that DMSO in combination with electrolytes reduced the electrical resistance of the skin by facilitating the absorption of these electrolytes while it was itself being absorbed.
DMSO in some instances will carry substances such as hydrocortisone or hexachlorophene into the deeper layers of the stratum corneum, producing a reservoir. This reservoir remains for 16 days and resists depletion by washing of the skin surface with soap, water, or alcohol.
The Ultimate Weapon Can't be controlled, banned or confiscated. Your weapon's your mind.