05-22-02 01:47
No 312192
Is there any method to make pure enantiomeric d-meth which doesn´t involve natural products like l-ephedrine l-PAC?
....i guess the method which ofcours exists could be applicable in some research fascility but deffinitly not my kitchen or garage.
/Thank you for your help
(Chief Bee)
05-22-02 01:55
No 312199
../rhodium /ampheta
(Hive Prodigy)
05-22-02 02:06
No 312205
There are also likely to be other possibilities involving organometallic syntheses. Many chiral agents have been developed for many syntheses involving these reactions. More information, I cannot produce, this is essentially all I know. My source (March's 5th) was very vague, and only consisting of about two sentences stating what I already stated.
Many of these catalysts revolve around the syntheses of alcohols and amines, so it is likely that such methods exist and are applicable here. What they are, I do not know as of yet.
PrimoPyro
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(Moderator)
05-22-02 02:16
No 312212
You can also use reductive alkylation using methylbenzylamine as found in:
../rhodium /reducti
Reductive Alkylation of alpha-Methylbenzylamine with 1-Phenyl-2-Propanone Followed by Hydrogenolysis:
Nichols et al., Asymmetric Synthesis of Psychotomimetic Phenylisopropylamines, J. Med. Chem. 16(5) (1973) 480-3. This procedure offers a route to dextro-amphetamine from phenyl-2-propanone
(Chief Bee)
05-22-02 02:19
No 312214
Synlett 651 (2002) has a large review article of stereospecific addition of organometallic reagents to imines to form optically pure amines. It even includes some 2,5-dimethoxyphenyl compounds.
(Hive Prodigy)
05-22-02 02:34
No 312221
99% ee? Does that mean 99% enantiomerically efficient by any chance? Just a wild guess.
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(Chief Bee)
05-22-02 03:01
No 312235
(Rated as: Good Explanation)
Enantiomeric excess. A racemic mixture is 0% ee, and a pure optical isomer is 100% ee. A 99% ee mixture consists of 99.5% of one isomer and 0.5% of the other. Stupid unit, I know.
(Hive Prodigy)
05-22-02 03:09
No 312240
I will remember this. The unit is ok, its value reminds me of the Proof system for alcohols, also redundant.
PrimoPyro
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