07-23-02 14:15
No 336119
Any suggestions for short, efficient and cheap ways to prepare 2-hydroxyacetophenone [Ph-C(=O)-CH2-OH]? The compound is commercially available, but too expensive to be of use. Ring-substituted derivatives would also be of interest.
Dr. Heckyll & Mr. Jive by Men at Work
...tells my tale.
(Hive Bee)
07-23-02 14:35
No 336122
Any suggestions for short, efficient and cheap ways to prepare 2-hydroxyacetophenone [Ph-C(=O)-CH2-OH]?
First, we have to acylate benzene with benzyloxyacetylchloride: put dry benzene and anhydrous AlCl3 in a flask and add the acetylchloride, let react at 50 °C
Then, we should remove the benzyl protecting group by catalytic hydrogenation with 0.5 weight eq. of 10 % Pd / C at 48 psi.
What can one do with this compound?
(Hive Bee)
07-23-02 16:15
No 336128
Interesting solution, Cyrax, but not quite satisfying for two reasons: benzyloxyacetylchloride is expensive and not broadly available, and catalytic hydrogenations, especially under pressure, are not generally available in smaller labs.
The compound of interest can easily be converted to 4-phenyl-4-oxazolin-2-one and substituted analogues which might have some pharmacological activity.
Dr. Heckyll & Mr. Jive by Men at Work
...tells my tale.
(Stoni's sexual toy)
07-23-02 17:26
No 336141
acetophenone ----> chloroacetophenone ---> desired product
OMG! These druggies are converting tear gas into drugs!
I'm not fat just horizontally disproportionate.