03-11-03 22:29
No 416026
Can 2,5 dimethoxy toluene be chlorinated in the same manner as toluene normaly would. Would the rest of the ring not bet chlorinated at the same time.
A friend told me of a synth from benzyl chlorides where two moles of benzyl chloride would both attach to zinc. The acetonitrile is added. A reducton with NaBH4 gives PEA. I am waiting to hear back from him for some refs. But what about the chlorination???
VL_
Start thinking more like a chemist and less like a criminal
(Hive Bee)
03-12-03 01:40
No 416082
hmmm...
I'd say yes. If you can chlorinate toluene with hypochlorite, i cant see why i would not work on 2,5-dimethoxytoluene. The only site, that possibly could be attached would be the 4-position. It is quite activated on the dimethylether-compound, but the worst think that could happen is that it gets chlorinated :) In that case i guess you could just brominate instead and then you'r a step closer anyhow.