CuCl/CuCl2/I2 a-iodination of propanoic acid - 90% , Hive Chemistry Discourse


		psyloxy (Hive Addict) 05-07-04 21:04 No 505628				CuCl/CuCl2/I2 a-iodination of propanoic acid - 90% (Rated as: good read)
						chem.lett. - 1984 - 1509/1510 alpha iodopropanoic acid (brief summary, read the 2 page .djvu!) CuCl (0.5 mol equiv), CuCl₂ (0.5 mol equiv), I₂(1 mol equiv) and propanoic acid (excess) are mixed and reacted at 120°C for 6h under N₂ atmosphere. Precipitated copper salts are filtered, excess acid is distilled off, product is recrystallized from hexane to afford a 90% yield based on I₂. where to go from here ? Post 212002 (Rhodium: "Easy nitroethane in quantitative yield", Methods Discourse) Post 333551 (Barium: "benzaldehydes to phenylacetones", Novel Discourse) w/the corresponding alkyl esters; prep. of methyl ester: J.Org.Chem.; 45; 14; 1980; 2831-2834. --psyloxy--



		moo (Hive Bee) 05-09-04 22:29 No 506045				Nice find!
						Nice find! _{fear fear hate hate}