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elosejohn
06-29-04 10:30
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<a href="https://www.the-hive.ws/forum/showflat.pl?Number=516256&page=3&view=&sb=&Search=&vc=&new=&start=0&xrated=y&&URLForums=" title="Click here to show this downrated post">methphenidate synth</a>
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<i title="This post has been downrated by the moderators">(Rated as: UTFSE!)</i>
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<font color="#FF0033">Rhodium</font><br>
<i>(<span title="The user's title at the time of posting">Chief Bee</span>)</i><br>
<span title="Posting date">06-29-04 16:59</span><br>
<span title="Link to this post by using the markup [516296]">No 516296</span><br>
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<b title="The subject of this post">threo-Methylphenidate Hydrochloride</b>
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The spelling "methylphenidate" may aid you in your searches. <br><br>Also see the following article:<br><br><b>Approaches to the Preparation of Enantiomerically Pure (2R,2'R)-(+)-threo-Methylphenidate Hydrochloride</b><br><i>Mahavir Prashad</i><br><a href="../rhodium/pdf
/threo-methylphenidate.pdf" target="_blank" title="Jump to this external site">Adv. Synth. Catal. 343(5), 379-392 (2001)</a> (../rhodium/pdf
/threo-methyl<wbr>phenidat<wbr>e.pdf)<br><br><b>Abstract</b><br>Various approaches to the preparation of enantiomerically pure (2R,2'R)-(+)-threo-methylphenidate hydrochloride (<b>1</b>) are reviewed. These approaches include synthesis using enantiomerically pure precursors obtained by resolution, classical and enzyme-based resolution approaches, enantioselective synthesis approaches, and approaches based on enantioselective synthesis of (2S,2'R)-erythro-methylphenidate followed by epimerization at the 2-position.
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<span title="The signature"><hr><sup>The Hive - Clandestine Chemists Without Borders</sup></span>
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